Preparation of 10-undecenoic acid based polyurethane/PCL fibers by electrospinning method and investigation of their antifungal properties
Yükleniyor...
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Nowadays, in the treatment of such fungal infections, antifungal drugs in various forms are one of the most preferred methods. These medications can be in the form of creams and lotions, shampoos, pills, suppositories, powders, or sprays. The dose of the drugs is adjusted according to the type and growth area of the fungus, the severity of the symptoms, and the medical history of the patients. Dressing materials with antifungal properties are an alternative treatment method used for the treatment of fungal skin infections. These covers not only treat fungal infections but also prevent their spread. Within the scope of this study, polyurethane-based wound dressing materials (PU-UDA/PCL) with antifungal properties were developed. Electrospining method was used to produce these dressing materials and the surface area of the wound dressing material was increased, thereby increasing the effect of antifungal property. Polypropylene glycol, glycerol, and catechin as polyol were preferred in polyurethane (PU) synthesis. These structures were polymerized with isophorone diisocyanate and modified with 10-undecenoic acid. Obtained 10-undecenoic acid modified polyurethane (PU-UDA) structures were transformed into wound dressing structure with polycaprolactone (PCL) by electrospinning method. Structural, morphological, and thermal properties of the wound dressing materials were analyzed with different instrumental analysis methods. The antifungal activities of PU-UDA/PCL were tested. Antifungal tests were performed on C. albicans and C. tropicalis. Therefore, PU-UDA/PCL series could be used as an efficient antifungal agent. Finally, it was determined that the obtained 10-undecenoic acid-based polyurethane fibers have a suitable structure and feature for the treatment of many fungal infections.
Açıklama
Received: 2 April 2022 / Revised: 2 June 2022 / Accepted: 8 June 2022
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
İdil Karaca Açarı, Department of Bioengineering, Faculty of Engineering and Natural Sciences, Malatya Turgut Ozal University, Malatya, 44210, Turkey. Filiz Boran, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Seda Kolak, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Eray Tatlıcı, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Özfer Yeşilada, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Süleyman Köytepe, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Burhan Ateş, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey.
© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
İdil Karaca Açarı, Department of Bioengineering, Faculty of Engineering and Natural Sciences, Malatya Turgut Ozal University, Malatya, 44210, Turkey. Filiz Boran, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Seda Kolak, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Eray Tatlıcı, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Özfer Yeşilada, Department of Biology, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Süleyman Köytepe, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey. Burhan Ateş, Department of Chemistry, Faculty of Science, Inonu University, Malatya, 44280, Turkey.
Anahtar Kelimeler
Polyurethane, Wound dressing material, Anti-fungal property
Kaynak
Polymer Bulletin
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
Sayı
Künye
Açarı, İ. K., Boran, F., Kolak, S., Tatlıcı, E., Yeşilada, Ö., Köytepe, S., & Ateş, B. (2022). Preparation of 10-undecenoic acid based polyurethane/PCL fibers by electrospinning method and investigation of their antifungal properties. Polymer Bulletin, 1-19.
