Caffeic Acid Phenethyl Ester (CAPE) inhibits growth of head and neck squamous cancer stem cells

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dc.contributor.authorCiftci-Yilmaz, Sultan
dc.contributor.authorYilmaz, Sultan
dc.contributor.authorGurel, Ayse
dc.contributor.authorOcal, Fikret Emre
dc.contributor.authorKeles, Alican
dc.contributor.authorBarut, Ahmet Emre
dc.contributor.authorIsik, Bulent
dc.date.accessioned2025-10-24T18:10:30Z
dc.date.available2025-10-24T18:10:30Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: Cancer stem cells are resistant to chemotherapy and radiotherapy and are implicated in tumor relapse and high patient mortality. Substances impairing cancer stem cell activity could be very useful as novel cancer therapeutics. Caffeic acid phenethyl ester (CAPE), a component of propolis, whose antitumor activity has been confirmed in several tumor types in vitro, has recently been shown to inhibit the growth of some cancer stem cell types. Methods: An ALDH1-positive fraction was isolated from UT-SCC-74A cells as cancer stem cells by magnetic-activated cell sorting. The isolated cells were characterized by sphere formation assay and biomarkers of cancer stem cells were analyzed by quantitative RT-PCR. To demonstrate the effect of CAPE on head and neck squamous cancer stem cells, XTT cell viability assays were performed. Results: Increasing concentrations of CAPE decrease the viability of head and neck squamous cancer stem cells. IC50 value was calculated from XTT results as 50.29 mu g/ml. Conclusion: CAPE has a growth inhibitory effect on head and neck squamous cancer stem cells in vitro.
dc.identifier.endpageE209
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84939178253
dc.identifier.scopusqualityQ2
dc.identifier.startpageE206
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4223
dc.identifier.volume38
dc.identifier.wosWOS:000359119100010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCanadian Soc Clinical Investigation
dc.relation.ispartofClinical And Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectCarcinoma; Apoptosis
dc.titleCaffeic Acid Phenethyl Ester (CAPE) inhibits growth of head and neck squamous cancer stem cells
dc.typeArticle

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