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Öğe Biomarkers in Hodgkin's Lymphoma(Crc Press-Taylor & Francis Group, 2014) Demir, Esin; Yilmaz, Burak; Gunduz, Mehmet; Gunduz, EsraLymphoma is a type of hematological cancer which occurs in the immune system, and specifically starts in lymphocytes. Lymphoma is basically of two types: Hodgkin's and non-Hodgkin's lymphoma (NHL). This chapter will specifically focus on Hodgkin's lymphoma (HL), whose subtypes are nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and classical Hodgkin's lymphoma (cHL). The characteristic cell types involved in these subtypes are different from each other. Biomarkers are another critical factor in making the correct identification of each subtype. Biomarkers can be categorized into different groups such as origin-related, chromosomal, cytokine, chemokine, and some important pathways-related markers. These biomarkers are not only important to distinguish subtypes but also critical to determine further treatment strategies for disease. Due to the importance of biomarker knowledge, we have reviewed significant HL biomarkers in this chapter.Öğe Designing an alternative reporter system for the GFP reporter system using Escherichia coli BL21 strain(Canadian Soc Clinical Investigation, 2015) Orhan, Ibrahim Y.; Karadag, Hizir A.; Bestepe, Furkan; Gul, Fatih; Uctepe, Eyyup; Yilmaz, BurakPurpose: Recombinant DNA technology can be used to transfer genetic material to bacteria [1]. To demonstrate that these recombinant bacteria can produce proteins by expressing the added genetic material, reporter systems are indispensable and mandatory [2,3]; hence, the improvement and development of reporter systems play a pivotal role in the progression of experimental method in recombinant DNA technology [2,4]. Methods: Viewing colour changes in the experimental area or on experiemntal subjects is simple, cheap and expedient [2, 5, 6]. In spite of their widespread utilization and the reliability of the consequence data, these reporter systems have some grave disadvantages [2,7,8]. In the absence of alternatives for these reporter systems, despite the serious handicaps and disadvantages, studies in recombinant DNA technology have been constricted by the infeasibility of such reporter systems [9,10]. Results: We focused on an alternative system to ameliorate current problems of common reporter systems - foremost the issue of time. The system in design had to be both potent and inexpensive. The main focus of the study was to design an alternative to the 2008 Nobel prize-winning GFP reporter system. Unlike the function of the GFP reporter system based on synthesizing colour absent in the medium as a means of response, we designed a system based on the degradation of dyes. Conclusion: This novel approach reduced the necessary time to attain a noticeable colour change and increased the certainty of the data.Öğe Lab-on-a-Chip Technology and Its Applications(Academic Press Ltd-Elsevier Science Ltd, 2018) Yilmaz, Burak; Yilmaz, Fazilet[Abstract Not Available]
