The Effects of MicroRNAs on Cardiomyopathy in a Rat Model of Streptozotocin-induced Diabetes Mellitus

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dc.contributor.authorDoğan, Aslıhan Şeyda
dc.contributor.authorPala, Mukaddes
dc.contributor.authorYılmaz, Şenay Görücü
dc.contributor.authorBECEREN, AYFER
dc.contributor.authorKarabulut, Aydın
dc.contributor.authorPolat, Yalçın
dc.contributor.authorELÇIOGLU, HATICE KÜBRA
dc.date.accessioned2025-10-24T18:03:25Z
dc.date.available2025-10-24T18:03:25Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: Diabetic cardiomyopathy (DCM) is characterized by complex pathophysiological events. miRNAs play a role in the DCM. In our study, the potential of miRNAs as a biomarker in the diagnosis and treatment of DCM was evaluated in the diabetes model induced by streptozotocin in rats. Methods: Therefore, miRNAs obtained from rat heart tissue were analyzed by microarray, and twelve miRNAs (rno-miR-200c-3p, rno-miR-129-5p, rno-miR-150-3p, rno-miR-3584-5p, rno-miR-34c-3p, rno-miR-342-3p, rno-miR-466b-3p, rno-miR-466c-3p, rno-miR-31a-3p, rno-miR-15b-5p, rno-miR-196b-3p, and rno-miR-208a-5p) with changed expression levels were validated by real-time polymerase chain reaction analysis. Results: As a result of the validation, it was determined that three miRNAs (rno-miR-15b-5p, rno-miR-196b-3p, and rno-miR-208a-5p) were downregulated, one miRNA (rno-miR-200c-3p) was upregulated (p<0.05). MiR-15b-5p, miR-196b-3p, miR-200c-3p, and miR-15b-5p are involved in the regulation of DCM, and the GRAP2 gene is one of the possible targets of these miRNAs. Conclusion: miR-200c-3p has diagnostic value and may be a biomarker candidate.
dc.identifier.doi10.14235/bas.galenos.2024.74429
dc.identifier.endpage44
dc.identifier.issn2148-2373
dc.identifier.issue1
dc.identifier.startpage35
dc.identifier.trdizinid1326372
dc.identifier.urihttps://doi.org/10.14235/bas.galenos.2024.74429
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1326372
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2208
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofBezmiâlem Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectStreptozotocin
dc.subjectbiomarker
dc.subjectmiRNA expression
dc.subjectDiabetic cardiomyopathy
dc.titleThe Effects of MicroRNAs on Cardiomyopathy in a Rat Model of Streptozotocin-induced Diabetes Mellitus
dc.typeArticle

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