Contribution of Polymorphism in PPAR? Untranslated Region to The Development of Axial Spondyloarthritis

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dc.contributor.authorAKBULUT, EKREM
dc.contributor.authorOzgen, Metin
dc.date.accessioned2025-10-24T18:03:56Z
dc.date.available2025-10-24T18:03:56Z
dc.date.issued2020
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe study aimed to contribute to the overall understanding of axial spondyloarthritis by investigating the polymorphism in 5’ untranslated region of peroxisome proliferator-activated receptor alpha gene in patients. The study included 194 patients and 197 controls recruited. The DNA obtained from the samples was genotyped by multiplex Polymerase Chain Reaction and then Matrix-Assisted Laser Desorption Ionization- Time of Flight Mass Spectrometry. Data were analyzed by logistic regression. Five polymorphic regions analyzed in this study, three of the sites were associated with disease risk. An allele in the rs1800204 polymorphic region (p < 0.001), C allele in the rs4253657 polymorphic region (p = 0.040) and C allele in the rs13909022 polymorphic region (p = 0.005) were associated with disease risk. The association of disease risk could not be detected with G and A alleles in the rs881740 (p = 0.456) and rs115640476 (p = 0.674) polymorphic regions, respectively. PPAR? 5' untranslated region polymorphism, which is shown to be associated with disease risk, is thought to contribute to the elucidation of the molecular mechanism of the disease. In axial spondyloarthritis, studying the effects of genetic changes in PPAR? on other genes with which it interacts will contribute to the full understanding of the molecular mechanism of the disease. Keywords: Axial spondyloarthritis; Peroxisome proliferator activated receptor alpha; Genetic predisposition; Disease risk.
dc.identifier.doi10.37094/adyujsci.650677
dc.identifier.endpage64
dc.identifier.issn2147-1630
dc.identifier.issn2146-586X
dc.identifier.issue1
dc.identifier.startpage55
dc.identifier.trdizinid469458
dc.identifier.urihttps://doi.org/10.37094/adyujsci.650677
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/469458
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2541
dc.identifier.volume10
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAdıyaman Üniversitesi Fen Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectGenel ve Dahili Tıp
dc.subjectRomatoloji
dc.titleContribution of Polymorphism in PPAR? Untranslated Region to The Development of Axial Spondyloarthritis
dc.typeArticle

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