Breast cancer stem cells and cellomics

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dc.contributor.authorDemir, Esin
dc.contributor.authorAtar, Bilge
dc.contributor.authorDhawan, Dipali
dc.contributor.authorBarh, Debmalya
dc.contributor.authorGündüz, Mehmet
dc.contributor.authorGündüz, Esra
dc.date.accessioned2025-10-24T18:06:40Z
dc.date.available2025-10-24T18:06:40Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOmics technologies are powerful high-throughput analytic tools to get inside whole-system level alterations of cancer cells. Since cancer stem cells are groups of vital cells in heterogeneous tumor populations, their omics analysis will enable better understanding in most controversial issues. These issues are mostly treatment resistance and metastatic ability of tumors. The relation between breast cancer patients' survival rates and stem cells in breast tumor has revealed the significance of breast cancer stem cells. The high tumor-forming capacity of these stem cells makes it necessary to get more comprehensive insight about their biology. Genomics, proteomics, and epigenomics are helpful tools for this purpose. The general step of these high-throughput methods is the isolation of breast cancer stem cells based on specific markers. Another shared feature of these omics approaches is to use a large set of interested genes, transcripts, or proteins. In addition to these two common key features, the remaining experimental setups may change from one to another omics analysis. The outcome of these approaches can yield some signatures, which will be mostly critical for later therapeutic strategies. Taken altogether, omics approaches not only reveal comprehensive understanding about breast cancer stem cells but also open the doors to more effective targeted therapies. © 2015 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1007/978-81-322-0843-3_12
dc.identifier.endpage263
dc.identifier.isbn8132208420
dc.identifier.isbn9788132208426
dc.identifier.isbn9788132208433
dc.identifier.scopus2-s2.0-84930729085
dc.identifier.scopusqualityN/A
dc.identifier.startpage245
dc.identifier.urihttps://doi.rog/10.1007/978-81-322-0843-3_12
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3117
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer India
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectBreast cancer stem cell
dc.subjectEpigenomics
dc.subjectGene signature
dc.subjectGenomics
dc.subjectOmics
dc.subjectProteomics
dc.titleBreast cancer stem cells and cellomics
dc.typeBook Chapter

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