Safe Inhalational Anesthetics in Patients With Coronary Artery Disease: Effects of Sevoflurane and Desflurane on Ischemia-Modified Albumin levels

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dc.contributor.authorSoyalp, Celaleddin
dc.contributor.authortürk, ömer
dc.contributor.authoröksüz, ersoy
dc.contributor.authorYUZKAT, NUREDDIN
dc.contributor.authorDEMİR, Canan
dc.contributor.authorDEMIR, HALIT
dc.date.accessioned2025-10-24T18:04:17Z
dc.date.available2025-10-24T18:04:17Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIntroduction: Sevoflurane and desflurane are commonly used anesthetic agents with known cardiac side effects. Ischemia -modified albumin (IMA) is a useful biomarker that increases in cardiac conditions. This study investiga tes the effects of desflurane and sevoflurane on cardiac parameters and IMA levels in patients with coronary artery disease (CAD). Materials and Methods: Sixty CAD patients aged over 18 years scheduled for elective surgery were enrolled. Patients were rand omly divided into two groups: group I, desflurane (D) (n=30) and group II, sevoflurane (S) (n=30). Pre - and post-operative cardiac parameters were recorded for each patient. IMA measurement in serum was determined spectrophotometrically. Results: Postoperative IMA levels were significantly higher than preoperative IMA levels in both groups. The rate of change between post- and pre-operative IMA levels was significantly lower in group S than in group D . Postoperative heart rate (HR) and mean arterial pressure (MAP) levels were significantly lower than preoperative HR and MAP levels in both groups, whereas no significant differenc es were found between the two groups with regard to pre- and post-operative HR and MAP levels. Conclusions: Sevoflurane is safer and has fewer cardiac side effects in CAD patients than desflurane. However, there is a need for comprehensive new studies evaluating large patient groups investigating this situation.
dc.identifier.doi10.5505/vmj.2024.18209
dc.identifier.endpage94
dc.identifier.issn1300-2694
dc.identifier.issn2587-0351
dc.identifier.issue2
dc.identifier.startpage89
dc.identifier.trdizinid1241093
dc.identifier.urihttps://doi.org/10.5505/vmj.2024.18209
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1241093
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2768
dc.identifier.volume31
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofVan Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectAnestezi
dc.subjectCoronary artery disease
dc.subjectSevoflurane
dc.subjectdesflurane
dc.subjectanesthesia
dc.subjectischemia-modified albumin
dc.titleSafe Inhalational Anesthetics in Patients With Coronary Artery Disease: Effects of Sevoflurane and Desflurane on Ischemia-Modified Albumin levels
dc.typeArticle

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