Association between surfactant protein B gene locus and acute bronchiolitis in infants

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dc.contributor.authorAYBEK, Sumeyya Deniz
dc.contributor.authorATES, HACI OMER
dc.contributor.authorSONDAS, Saime SEZER
dc.contributor.authorGul, Ali
dc.contributor.authorTAKCI, SAHIN
dc.contributor.authorSEYYAH, BUKET ALTINTAS
dc.date.accessioned2025-10-24T18:03:29Z
dc.date.available2025-10-24T18:03:29Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: The aim of this study was to investigate whether there is a relationship between surfactant protein B (SFTPB) C1580T polymorphism and acute bronchiolitis. Materials and Methods: The study analyzed the allele frequency and genotype distribution for the SFTPB C1580T polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 103 acute bronchiolitis infants and 102 healthy infants. Results: The results showed no association between SFTPB C1580T polymorphism and clinical characteristics of acute bronchiolitis. The distribution of the CT genotype was higher in acute bronchiolitis infants (43%) than in healthy subjects (39%) and distribution of the TT genotype was found lower in acute bronchiolitis infants (38%) than in healthy subjects (41%). No significant differences in genotype distribution and allele frequency for the SFTPB C1580T polymorphism were found between case group and control group Conclusion: SFTPB C1580T gene polymorphism plays no important role in susceptibility to acute bronchiolitis. Further work on the relevance of SFTPB C1580T polymorphism in larger cohorts will require validating our results.
dc.identifier.doi10.17826/cumj.1124468
dc.identifier.endpage1446
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue4
dc.identifier.startpage1440
dc.identifier.trdizinid1149661
dc.identifier.urihttps://doi.org/10.17826/cumj.1124468
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1149661
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2279
dc.identifier.volume47
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofCukurova Medical Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectBiyoloji
dc.subjectMikrobiyoloji
dc.subjectKulak
dc.subjectBurun
dc.subjectBoğaz
dc.subjectPediatri
dc.subjectGenetic polymorphism
dc.subjectAcute bronchiolitis
dc.subjectSFTPB gene
dc.subjectsurfactant protein
dc.titleAssociation between surfactant protein B gene locus and acute bronchiolitis in infants
dc.typeArticle

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