Suppression of bromodomain-containing protein 4 by shRNA: A new approach for cancer treatment

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dc.contributor.authorKaya, Turan
dc.contributor.authorKahraman, Berke
dc.contributor.authorBazarov, Nurgeldi
dc.contributor.authorToker, Alperen S.
dc.contributor.authorCelik, Ayse
dc.contributor.authorCigdem, Sadik
dc.contributor.authorGunduz, Esra
dc.date.accessioned2025-10-24T18:10:15Z
dc.date.available2025-10-24T18:10:15Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: MYC is a transcription factor coding gene that is believed to control 15% of the genes in the entire human genome. The central role of c-MYC in cancer pathogenesis makes it a major therapeutic target in field of anticancer agent development. Methods: We targeted the acetyl-lysine binding modules or bromodomains, which are associated with c-MYC transcriptional activation. Results: Sequence specific inhibition of BET bromodomains with small hairpin RNAs (shRNAs) resulted in cessation of cellular proliferation in different cancer cell lines. Unlike previous studies on inhibition of bromodomains with selective small-molecule inhibitors, our study revealed the significant role of BET bromodomains in solid tumours and also highlighted the ease of RNA interference (RNAi) methodology for inhibition of bromodomain translation. Conclusion: The degree of influence of BET bromodomain inhibition on proliferation in five cancer cell lines established it as the major target in malignancies characterized by activation of c-MYC.
dc.identifier.endpageS13
dc.identifier.issn0147-958X
dc.identifier.issn1488-2353
dc.identifier.issue6
dc.identifier.startpageS7
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4070
dc.identifier.volume39
dc.identifier.wosWOS:000389725000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherCanadian Soc Clinical Investigation
dc.relation.ispartofClinical And Investigative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectRna-Polymerase-Ii; Mammalian-Cells; P-Tefb; Brd4; Recruitment; Stimulation; Elongation; Mechanisms; Chromatin
dc.titleSuppression of bromodomain-containing protein 4 by shRNA: A new approach for cancer treatment
dc.typeArticle

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