Evaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism

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dc.contributor.authorUçar, Fatma
dc.contributor.authorAkyol, Sumeyya
dc.contributor.authorÖztürk, Gülfer
dc.contributor.authorGiniş, Zeynep
dc.contributor.authorErden, Gönül
dc.contributor.authorTaslipinara, Mine Yavuz
dc.contributor.authorArzuhala, Abdullah Ercan
dc.date.accessioned2025-10-24T18:06:51Z
dc.date.available2025-10-24T18:06:51Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIncreasing numbers of researches have indicated the relationship between serum vitamin D level and several autoimmune diseases, because it has important roles in immune regulation. However, the role of vitamin D in the etiopathogenesis of these diseases is not well understood. Similarly, the detailed mechanism of vitamin D action on thyroid hormone metabolism and autoimmune thyroid diseases is still poorly understood. It was recently reported that patients with autoimmune thyroid disease showed lower vitamin D levels. However, there are few studies dealing with vitamin D status in elderly patients with subclinical hypothyroidism. We therefore aimed to investigate vitamin D levels in elderly patients with subclinical hypothyroidism. In the present study, a total of 37 patients (>70 years old) with subclinical hypothyroidism and 40 healthy controls (>70 years old) were retrospectively analyzed. Serum levels of free triiodothyronine (fT3), free thyroxine (fT4) and thyroid-stimulating hormone (TSH) were analyzed by chemiluminescence immunoassay (Centaur XP, Siemens Healthcare Diagnostics Inc., Tarrytown, USA). Serum levels of 25-Hydroxy vitamin D (25-OH D) were measured by chemiluminescence immunoassay (DiaSorin, Liaison, Italy). Serum anti thyroid peroxidase (anti-TPO) and anti thyroglobulin (anti-TG) were measured using a solid-phase, enzyme-labeled, chemiluminenescent sequential immunometric assay (Immulite 2000 XPi, Siemens Healthcare Diagnostics Inc., Tarrytown, USA). There was no significant difference between groups in terms of age and gender distribution. Serum TSH, anti-TPO and anti-TG levels in elderly patients with subclinical hypothyroidism showed higher values than healthy controls as expected. Serum 25-OH D levels in elderly patients with subclinical hypothyroidism were lower than healthy controls (p<0.001). These data may suggest association between serum 25-OH D levels and subclinical hypothyroidism in elderly patients. Further studies are needed to determine whether vitamin D insufficiency is a casual factor in the etiopathogenesis of subclinical hypothyroidism in elderly patients or rather a consequence of the disease. © 2016 Elsevier B.V., All rights reserved.
dc.identifier.doi10.5835/jecm.omu.31.02.003
dc.identifier.endpage80
dc.identifier.issn1309-4483
dc.identifier.issn1309-5129
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85006555695
dc.identifier.scopusqualityQ4
dc.identifier.startpage77
dc.identifier.urihttps://doi.rog/10.5835/jecm.omu.31.02.003
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3225
dc.identifier.volume31
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherOndokuz Mayis Universitesi Samsun 55139
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectAutoantibodies
dc.subjectElderly
dc.subjectSubclinical hypothyroidism
dc.subjectVitamin D
dc.titleEvaluation of serum vitamin D levels in elderly patients with subclinical hypothyroidism
dc.typeArticle

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