Synthesis, Antiproliferative Activity and In Silico Studies of Chalcones Derived From 4-(Imidazole-1-yl)Acetophenone

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dc.contributor.authorAKTAR, BEDRİYE SEDA KURSUN
dc.contributor.authorAL-KARABASH, ABDULRAHEEM MUSTAFA IBRAHIM
dc.contributor.authorYaglioglu, Ayse Sahin
dc.contributor.authororuç-emre, emine elçin
dc.date.accessioned2025-10-24T18:03:36Z
dc.date.available2025-10-24T18:03:36Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIn this study, the synthesis of chalcone compounds (1-11) derived from 4-(imidazol-1-yl)acetophenone and the structure determination of these compounds by various spectroscopic methods were carried out. The anticancer activities of compounds 1-11 were examined against HeLa and PC-3 cancer cells at four different concentrations (100, 50, 25, and 5 µM) using the BrdU ELISA assay. It was determined that all molecules except compounds 1 and 6 in HeLa cancer cells and compounds 2 and 8 against PC-3 cancer cells were more active against HeLa and PC-3 than the standard drug 5-fluorouracil (5-FU). The best activity against PC-3 cancer cells was compound 4 (IC50: 1.39±0.00 µM). In addition, compound 11 (IC50: 1.58±0.01 µM) was found to have the highest activity against HeLa cancer cells. Compound 4 against PC-3 cancer cell and compound 11 against HeLa cancer cell displayed cell selective activity. The ADME properties and drug similarities of the molecules 1-11 using the SwissADME software were investigated. According to these properties, compounds 1-11 were found to obey Lipinski rules.
dc.identifier.doi10.18596/jotcsa.1313595
dc.identifier.endpage868
dc.identifier.issn2149-0120
dc.identifier.issue3
dc.identifier.startpage861
dc.identifier.trdizinid1195528
dc.identifier.urihttps://doi.org/10.18596/jotcsa.1313595
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1195528
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2324
dc.identifier.volume10
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofJournal of the Turkish Chemical Society, Section A: Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectKimya
dc.subjectTıbbi
dc.subjectBiyoteknoloji ve Uygulamalı Mikrobiyoloji
dc.subjectOnkoloji
dc.subjectADME
dc.subjectantiproliferative activity
dc.subjectHeLa cell line
dc.subjectin silico.
dc.subjectPC-3 cell line
dc.titleSynthesis, Antiproliferative Activity and In Silico Studies of Chalcones Derived From 4-(Imidazole-1-yl)Acetophenone
dc.typeArticle

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