Endothelin-1 and Nitric Oxide levels in exudative age-related macular degeneration

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dc.contributor.authorTotan, Yüksel
dc.contributor.authorKoca, Cemile
dc.contributor.authorErdurmuş, Mesut
dc.contributor.authorKeskin, Uğurcan
dc.contributor.authorYiğitoğlu, Ramazan
dc.date.accessioned2025-10-24T18:06:44Z
dc.date.available2025-10-24T18:06:44Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: To evaluate plasma levels of endothelin-1 (ET-1) and nitric oxide (NO) in patients with exudative age-related macular degeneration (AMD). Methods: In this study, ET-1 levels, as well as nitrite plus nitrate concentrations as an indicator of plasma NO level, were measured in the plasma of 20 subjects with exudative AMD and compared with 20 healthy age and sex matched controls. Results: Mean plasma ET-1 level was significantly higher in exudative AMD patients as compared to control subjects (0.35 ± 0.06 fmol/ml versus 0.17 ± 0.03 fmol/ml, P = 0.015). Patients with exudative AMD also showed significantly lower mean plasma levels of nitrite plus nitrate as compared to the controls (58.9 ± 2.7 ?mol/l versus 82.6 ± 5.9 ?mol/l, P = 0.001). Conclusion: Increased concentrations of ET-1 and reduced levels of NO in the plasma may suggest an imbalance between vasoconstrictor and vasodilator agents, respectively, as a reflection of endothelial dysfunction in the pathogenesis of AMD. These findings may also imply the role of vasoconstriction in exudative AMD. © 2020 Elsevier B.V., All rights reserved.
dc.identifier.doi10.4103/2008-322X.163765
dc.identifier.endpage154
dc.identifier.issn2008-2010
dc.identifier.issn2008-322X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-84940778840
dc.identifier.scopusqualityQ2
dc.identifier.startpage151
dc.identifier.urihttps://doi.rog/10.4103/2008-322X.163765
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3185
dc.identifier.volume10
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications journal@jovr.org
dc.relation.ispartofJournal of Ophthalmic and Vision Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzScopus_20251023
dc.subjectAge-related Macular Degeneration
dc.subjectEndothelial Dysfunction
dc.subjectEndothelin-1
dc.subjectNitric Oxide
dc.titleEndothelin-1 and Nitric Oxide levels in exudative age-related macular degeneration
dc.typeArticle

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