Nine healthy deliveries in four pregnant women with enzyme replacement therapy in Gaucher disease

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dc.contributor.authorALADAĞ, HÜLYA
dc.contributor.authorAladag, Murat
dc.date.accessioned2025-10-24T18:04:10Z
dc.date.available2025-10-24T18:04:10Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim: Our aim is to present the pregnancy and delivery cases that occurred with success- ful enzyme replacement therapy (ERT) in our female Gaucher patients, whom we have followed and treated for years. Materials and Methods: We tried to retrospectively evaluate and present 9 pregnancy and delivery events that occurred with successful ERT in 4 of our 32 Gaucher patients, whom we have been following up and treated for years in our clinic. Patient monitoring parameters include regular clinical, biological, and radiological evaluations. We checked our Gaucher’s disease (GD) patients regularly at regular intervals before and during preg- nancy for their hemoglobin, platelet, leukocyte, ferritin, blood sugar and creatinine levels. Results: 4 of the 32 cases were children, age range (4-16 years), 16 women age range (22- 68 years), 12 men age range (34-72 years). Four of our cases have not received treatment yet. 12 of the female cases are receiving regular ERT (3 months-14 years). Of the male cases, 9 were receiving ERT (3-9) and 3 were not taking medication. One of our cases gave birth to a total of 4 children, first twins and then two single children with an interval of 3 years. Two of our patients had two deliveries and one of our patients with both Gaucher and SLE disease gave birth. Pregnant patients came to check-ups more frequently during pregnancy and were followed up and treated with a multidisciplinary approach each time they came. The ERT treatments of the patients were increased during pregnancy as the patient gained weight, and the symptoms that increased during pregnancy were relieved by increasing the dose. Conclusion: As a result, in our study, we observed that there was a healthy and successful pregnancy and delivery with ERT, which was started at the appropriate time and given at the appropriate dose. Comprehensive studies involving more cases are required in this regard.
dc.identifier.doi10.5455/annalsmedres.2023.01.018
dc.identifier.endpage281
dc.identifier.issn2636-7688
dc.identifier.issue2
dc.identifier.startpage278
dc.identifier.trdizinid1162294
dc.identifier.urihttps://doi.org/10.5455/annalsmedres.2023.01.018
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1162294
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2697
dc.identifier.volume30
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofAnnals of Medical Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectKadın Hastalıkları ve Doğum
dc.subjectPatoloji
dc.subjectKimya
dc.subjectTıbbi
dc.subjectGenetik ve Kalıtım
dc.subjectPregnancy
dc.subjectGaucher’s disease (GD)
dc.subjectEnzyme replacement therapy (ERT)
dc.subjectSystemic lupus erythematosus (SLE)
dc.titleNine healthy deliveries in four pregnant women with enzyme replacement therapy in Gaucher disease
dc.typeArticle

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