Comparative Genomic and Proteomic Analysis of SARS CoV-2 - with Potential Mutation Probabilities and Drug Targeting

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dc.contributor.authorAKBULUT, EKREM
dc.date.accessioned2025-10-24T18:03:36Z
dc.date.available2025-10-24T18:03:36Z
dc.date.issued2020
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractCOVID-19 caused by the highly pathogenic SARS-CoV-2 has caused the death of over 1.69 million people worldwide. High mutation potentials of RNA viruses require the determination of the most accurate structure to be targeted for treatment. In this study, comparative genomic and proteomic analyses of SARS-CoV-2 were performed using SARS-CoV and MERS-CoV, and the mutation potential of the residues was analyzed using bioinformatics tools. SARS-CoV-2 was found to be 80.08% and 58.79% similar to SARS-CoV and MERSCoV, respectively, at the nucleotide level. G+C content were 38%, 40.8% and 41.2% for SARS-CoV-2, SARS-CoV and MERS-CoV, respectively. 5?UTR G+C content was 44.6%, 43.5% and 44.7% for SARSCoV-2, MERS-CoV and SARS-CoV, respectively. At the amino acid level, SARS-CoV-2 and SARS-CoV showed 83.3% similarity, whereas SARS-CoV-2 and MERS-CoV showed 42.5% similarity. The E, M, N and S proteins of SARS-CoV-2 and SARS-CoV were found to be 94%, 90.1%, 90.6% and 76.1% identical, respectively. For SARS-CoV-2, 14 residues with a high risk of mutation and their repeat numbers in the genome were identified. Data from this study reveal that non-functional conserved proteins such as ORF6 and ORF7b with low risk of mutation may be appropriate targets for the treatment because of their functional properties.
dc.identifier.doi10.18185/erzifbed.758406
dc.identifier.endpage1197
dc.identifier.issn1307-9085
dc.identifier.issn2149-4584
dc.identifier.issue3
dc.identifier.startpage1187
dc.identifier.trdizinid476764
dc.identifier.urihttps://doi.org/10.18185/erzifbed.758406
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/476764
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2317
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofErzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectMikrobiyoloji
dc.subjectViroloji
dc.subjectEnfeksiyon Hastalıkları
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.titleComparative Genomic and Proteomic Analysis of SARS CoV-2 - with Potential Mutation Probabilities and Drug Targeting
dc.typeArticle

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