Antioxidant effect of grape molasses in rat heart tissues

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dc.contributor.authorKıran, Tuğba Raika
dc.contributor.authorOtlu, Önder
dc.contributor.authorKarabulut, Ercan
dc.contributor.authorPakdemirli, Ahu
dc.contributor.authorÖzcan, Nermin
dc.date.accessioned2022-03-15T07:09:49Z
dc.date.available2022-03-15T07:09:49Z
dc.date.issued2019-08-17en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractGrape molasses, which is rich in mineral substances such as flavonoids, polyphenol, antioxidants, iron, calcium, phosphorus, potassium, and magnesium is a natural nutrient, that is concentrated with boiling without adding any additive. In this study, we aimed to investigate the effects of molasses and resveratrol diets on oxidative stress parameters in cardiac damage induced with 7,12-dimethylbenz(a)anthracene (DMBA). A total of 42 Wistar albino female rats were divided into six groups with seven in each. Control group was administered subcutaneous injection of 1 mL mixture including 20 mL sesame oil + 30 mL Dimethyl Sulphoxyde (DMSO); DMBA group received subcutaneous injection of 10 mg/Kg DMBA on the 0th and 7th days. DMBA + Molasses group received DMBA application and feed containing 20 % molasses; DMBA + Resveratrol group received subcutaneous injection of DMBA + 10 mg/Kg resveratrol a day. Molasses group received feed with 20 % molasses, and Resveratrol group received subcutaneous injection of 10 mg/Kg resveratrol a day. There was a statistically significant difference between the DMBA group and DMBA + Molasses, control, resveratrol and molasses groups in terms of nitric oxide activity. There was a statistically significant difference between the DMBA group and DMBA + Resveratrol, DMBA + Molasses, control, molasses and resveratrol groups in term of malondialdehyde (MDA) activity. There was a statistically significant difference between DMBA groups, and DMBA + Molasses, DMBA + Resveratrol, and control groups in terms of glutathione (GSH) activity. Based on these results, it could be said that grape molasses could provide protection against oxidative stress as resveratrol, decreasing the risk of damage by free radicals.en_US
dc.identifier.citationKıran, T. R., Otlu, Ö., Karabulut, E., Pakdemirli, A., & Özcan, N. (2019). Antioxidant effect of grape molasses in rat heart tissues.en_US
dc.identifier.doi10.5455/medscience.2019.08.9092
dc.identifier.endpage819en_US
dc.identifier.issue4en_US
dc.identifier.startpage814en_US
dc.identifier.uri10.5455/medscience.2019.08.9092
dc.identifier.urihttps://hdl.handle.net/20.500.12899/632
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorOtlu, Önder
dc.language.isoenen_US
dc.relation.ispartofMedicine Science International Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası - Editör Denetimli Dergien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGrape Molassesen_US
dc.subjectResveratrolen_US
dc.subjectOxidative Stressen_US
dc.subjectDMBAen_US
dc.subjectHearten_US
dc.titleAntioxidant effect of grape molasses in rat heart tissuesen_US
dc.typeArticleen_US

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