Synthesis and investigation of antiproliferative activity of Ru-NHC complexes against C6 and HeLa cancer cells

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dc.contributor.authorPAŞAHAN, RAMAZAN
dc.contributor.authorAkkoç, Mitat
dc.contributor.authorYAŞAR, Şeyma
dc.contributor.authorKöprülü, Tuğba Kul
dc.contributor.authortekin, saban
dc.contributor.authoryaşar, sedat
dc.contributor.authorÖzdemir, İsmail
dc.date.accessioned2025-10-24T18:04:18Z
dc.date.available2025-10-24T18:04:18Z
dc.date.issued2022
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe 2-methylpyridine, 2-diethylaminoethyl, and isopentyl linked a series of symmetric and unsymmetric benzimidazolium salts 2a-e were prepared and used in the synthesis of silver-N-heterocyclic carbene (NHC) complexes (3a-e). The Ru(II)-NHC complexes (4a-h) were synthesized via transmetalation reaction from 3a-e. 4a-h complexes were converted to Ru(II)-NHC.HCl complexes (5a- h) by HCl solution of diethyl ether and characterized by different spectroscopic techniques such as $^1H and ^{13}C$ NMR, LC/MS-Q-TOF, FT-IR, elemental analysis, and melting point detection. We examined the effect of the structural difference of complexes on anticancer activity via different arenes and metal centers. Antiproliferative activity of 5a-h and 3a was tested against human cervix adenocarcinoma (HeLa) and rat glioblastoma (C6) cell lines by ELISA assay. The $IC_{50}$ value of 5b, 5c and 5e complexes exhibited good cytotoxic activity than cisplatin on C6 (14.2 ± 0.5 mM; 16.2 ± 0.4 mM; 24.2 ± 0.7 mM, respectively) and HeLa (11.1 ± 0.5 mM; 13.7 ± 0.3 mM; 22.8 ± 0.8 mM, respectively) cell lines.
dc.identifier.doi10.55730/1300-0527.3418
dc.identifier.endpage1109
dc.identifier.issn1300-0527
dc.identifier.issn1303-6130
dc.identifier.issue4
dc.identifier.startpage1097
dc.identifier.trdizinid1141986
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3418
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1141986
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2779
dc.identifier.volume46
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Chemistry
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzTR-Dizin_20251023
dc.subjectKimya
dc.subjectTıbbi
dc.subjectOnkoloji
dc.subjectN-heterocyclic carbene
dc.subjectHeLa
dc.subjectsilver
dc.subjectC6
dc.subjectantiproliferative activity
dc.subjectruthenium
dc.titleSynthesis and investigation of antiproliferative activity of Ru-NHC complexes against C6 and HeLa cancer cells
dc.typeArticle

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