Parkınson ve parkınson plus hastalarının beyin hacimlerinin karşılaştırılması
Küçük Resim Yok
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Malatya Turgut Özal Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada Parkinson Hastalığı (PH) ve Parkinson plus hastalığı (PPH) tanılı bireylerin beyin hacimlerini, sağlıklı bireylerin beyin hacimleri ile karşılaştırarak aralarındaki hacimsel farkı bulmayı amaçladık. Çalışmaya PH tanılı 25 birey ve PPH tanılı 25 birey, 25 sağlıklı birey dahil edildi. Çalışmamızın PPH'nin ve PH'ye kıyasla putamen (p=0.03635) hacminin azaldığı ve corpus amygdaloideum hacim asimetrisinin yüzdelik değeri (p=0.03946)'nde artış olduğu, PPH'nin kontrol grubuna göre lateral ventrikül (p=0.01085), putamen (p=0.01461) volümlerinde azalma olduğu, lateral ventrikül hacim asimetrisinin yüzdelik değeri (p=0.00816)'nde, nucleus caudatus (p<0.001), globus pallidus hacim asimetrisinin yüzdelik değeri (p<0.001) ve corpus amygdaloideum hacim asimetrisinin yüzdelik değeri (p=0.00208)'nde artış olduğu belirlendi. PH'nin kontrol grubuna göre globus pallidus hacim asimetrisinin yüzdelik değeri ve nucleus caudatus (p<0.001, p<0.001) hacimlarinde artış olduğu belirlendi. Diğer parametrelerde istatistiksel olarak anlamlı fark olmadığı bulundu. Sağ/sol taraf değerlendirmesinde; PPH'de sağ/sol corpus amygdaloideum ve sağ/sol nucleus accumbens hacmindeki değişim istatistiksel olarak anlamlıyken, bu fark PH ve kontrol grubunda anlamlı değildir. Bununla birlikte PH'nin sağ/sol lateral ventrikül hacminde isatistiksel olarak anlamlı fark vardır. Çalışmamızın sonucunda globus pallidus hacim asimetrisinin yüzdelik değerinin ve nucleus caudatus hacimlerinin bilinmesinin, PH ile PPH teşhisinde önemli olduğunu, putamen ile amygdoleideum hacim asimetrisinin yüzdelik değerinin bilinmesinin ise PPH'nin, PH'den ayırıcı tanıda kritik bir öneme sahip olduğunu düşünmekteyiz.
In this study, we aimed to find the volumetric difference between the brain volumes of individuals diagnosed with Parkinson's Disease (PD) and Parkinson plus disease (PPD) by comparing them with the brain volumes of healthy individuals. In the study 25 individuals diagnosed with PH, 25 individuals diagnosed with PPH, 25 healthy individuals were included in the study. İt was determined that in our study, compared to PPD and PD, there was a decrease in putamen volume (p=0.03635) and an increase in percentage value of corpus amygdaloideum volume asymmetry (p=0.03946). Between the PD and control groups, it was found that there was an increase in nucleus caudatus volumes and percentage value of globus pallidus volume asymmetry (p<0.001, p<0.001). Other parameters did not show any statistically significant difference. In the right/left side evaluation, the alteration in the volume of the right/left corpus amygdaloideum and right/left nucleus accumbens in PPD was statistically significant, while this difference was not significant in the PD and control group. In addition, in the PD group, there is a statistically significant difference in the right/left lateral ventricular volume. As a result of our study, we concluded that determining the percentage value of globus pallidus volume asymmetry and nucleus caudatus volumes is important in the diagnosis of PD and PPD, and determining the putamen and percentage value of corpus amygdaloideum volume asymmetry is of critical importance in the differential diagnosis of PPD from PD.
In this study, we aimed to find the volumetric difference between the brain volumes of individuals diagnosed with Parkinson's Disease (PD) and Parkinson plus disease (PPD) by comparing them with the brain volumes of healthy individuals. In the study 25 individuals diagnosed with PH, 25 individuals diagnosed with PPH, 25 healthy individuals were included in the study. İt was determined that in our study, compared to PPD and PD, there was a decrease in putamen volume (p=0.03635) and an increase in percentage value of corpus amygdaloideum volume asymmetry (p=0.03946). Between the PD and control groups, it was found that there was an increase in nucleus caudatus volumes and percentage value of globus pallidus volume asymmetry (p<0.001, p<0.001). Other parameters did not show any statistically significant difference. In the right/left side evaluation, the alteration in the volume of the right/left corpus amygdaloideum and right/left nucleus accumbens in PPD was statistically significant, while this difference was not significant in the PD and control group. In addition, in the PD group, there is a statistically significant difference in the right/left lateral ventricular volume. As a result of our study, we concluded that determining the percentage value of globus pallidus volume asymmetry and nucleus caudatus volumes is important in the diagnosis of PD and PPD, and determining the putamen and percentage value of corpus amygdaloideum volume asymmetry is of critical importance in the differential diagnosis of PPD from PD.
Açıklama
Lisansüstü Eğitim Enstitüsü, Anatomi Ana Bilim Dalı
Anahtar Kelimeler
Anatomi, Anatomy
