Omics of hereditary breast cancer

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dc.contributor.authorMoroski-Erkul, Catherine A.
dc.contributor.authorYılmaz, Burak
dc.contributor.authorGündüz, Esra
dc.contributor.authorGündüz, Mehmet
dc.date.accessioned2025-10-24T18:06:40Z
dc.date.available2025-10-24T18:06:40Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBreast cancer is the leading cause of cancer-related deaths among women worldwide. Although advances in our understanding of this disease have been made in the last decade, the available treatments remain inadequate, particularly for the more intractable forms of breast cancer. Hereditary or familial breast cancer poses a particularly difficult challenge as only a few susceptibility genes with high penetrance have been identified, namely, BRCA1 and BRCA2. It is now suspected that the majority of hereditary and familial breast cancers are caused by various combinations of several moderate- and/or low-penetrance genes. Recent developments in research methodologies and conceptual frameworks within biology have revolutionized the study of cancer. This systems approach, which emphasizes a holistic understanding of biological systems, is referred to generally as omics. A decade of omics research has led to the identification of many new therapeutic targets and biomarkers, allowing for more accurate and earlier diagnosis and treatment of the wide spectrum of diseases that are collectively referred to as breast cancer. Here we review the contributions of several omics fields to our understanding of hereditary and familial breast cancer, namely, genomics, transcriptomics, proteomics, and metabolomics. © 2015 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1007/978-81-322-0843-3_2
dc.identifier.endpage40
dc.identifier.isbn8132208420
dc.identifier.isbn9788132208426
dc.identifier.isbn9788132208433
dc.identifier.scopus2-s2.0-84930732031
dc.identifier.scopusqualityN/A
dc.identifier.startpage17
dc.identifier.urihttps://doi.rog/10.1007/978-81-322-0843-3_2
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3119
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer India
dc.relation.publicationcategoryKitap Bölümü - Uluslararası
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectGenomics
dc.subjectHereditary breast cancer
dc.subjectMetabolomics
dc.subjectProteomics
dc.subjectTranscriptomics
dc.titleOmics of hereditary breast cancer
dc.typeBook Chapter

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