Ontraceptive vaccines: Review
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S. aysea@turkiyeklinikleri.com Turkocagi Caddesi No. 30 Balgat 06520
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The population growth and unintended pregnancies are major public health issues worldwide. The world population has exceeded 6.8 billion and is increasing by 1 billion every 12 years. An estimated 80 million women have unintended or unwanted pregnancies worldwide annually and 45 million of these end in abortion. Most of these women use some type of contraceptive. All of these means there is an absolute need for an alternative form of contraceptive. Basic principle of immunocontraception is using the immune system to provide protection against an unwanted pregnancy. Since the 1900s, several antigens have been used as target for developing contraceptive vaccines. According to the targets, contraceptive vaccines can be categorized into three groups. First group GnRH, FSH,LH based vaccines inhibits production of gametes; the second group antisperm and zona pellucida based vaccines, impairs gamete outcome and the third group blocks the human chorionic gonadotropin (hCG) after fertilization. Although the vaccines targeted hCG that has undergone phase 1 and phase 2 clinical trials in women as a contraceptive vaccines with the encouraging results; nevertheless immunocontraception for the human use will not be available in the near future. One of the major challenges for the contraceptive vaccines is inter-individual wide variation of the immune response. In the future, in relation to progress in the field of genomics, proteomics and immunology; more specific targets and more potent vaccines will be developed. The aim of this article is to review and summarise past and present knowledge about contraceptive vaccines researchs. Cop yright & 2016 by Tür ki ye Kli nik le ri. © 2018 Elsevier B.V., All rights reserved.
Açıklama
Anahtar Kelimeler
Chorionic gonadotropin, beta subunit, human, Contraception, immunologic, Sperm-ovum interactions, Vaccines, contraceptive
Kaynak
Turkiye Klinikleri Jinekoloji Obstetrik
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
26
Sayı
1
