Can hyaluronan binding assay predict the outcome of intrauterine insemination in couples with unexplained or mild male factor infertility?

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dc.contributor.authorYildirim, Melahat
dc.contributor.authorDuvan, Zehra Candan İltemir
dc.contributor.authorPekel, Aslihan
dc.contributor.authorAyrim, Aylin
dc.contributor.authorKafali, Hasan
dc.date.accessioned2025-10-24T18:06:53Z
dc.date.available2025-10-24T18:06:53Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: The purpose of this study was to evaluate the prognostic effect of Hyaluronan Binding Assay (HBA) which has been used as a method of sperm selection for intracytoplasmic sperm injection procedure, on the outcome of intrauterine insemination (IUI) in couples with unexplained or mild male factor infertility. Methods: 77 infertile couples were enrolled in our study. On the day of IUI procedure, HBA test was performed by using fresh semen samples, and the rates of sperm binding to HBA were calculated. HBA values and semen parameters were compared. Fisher exact test was used to evaluate the relationship between HBA ratio and pregnancy status. Mann-Whitney U test was used to compare quantitative variables between pregnant and non-pregnant groups. The p<0.05 was considered statistically significant. Results: In this study, HBA ratio was 69(29.25%) and pregnancy rate was 14.29%. A significant positive correlation between HBA and total motile sperm count, inseminating sperm count, progressive motility, morphology, and sperm concentration (p<0.001, p<0.001, p:0.007, p<0.003, p:0.003 respectively) was observed. Although HBA values in pregnant group were higher than those in non-pregnant group, this result did not reach the statistically significant level (HBA: 67(20%) for nonpregnant group, 80.5(21.3%) for pregnant group). Also, no relationship between HBA values and pregnancy status was found. Moreover, there was no significant correlation between pregnancy status and HBA ratios based on the suggested cut-off value of 60 in literature (p=0.425). Conclusion: HBA does not predict the IUI outcome in couples with unexplained infertility or mild male factor infertility, but it can be used together with semen parameters to verify sperm quality. © 2015 Elsevier B.V., All rights reserved.
dc.identifier.endpage23
dc.identifier.issn2228-5482
dc.identifier.issn2251-676X
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84937121933
dc.identifier.scopusqualityQ3
dc.identifier.startpage18
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3269
dc.identifier.volume16
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAvicenna Research Institute ajmb@avicenna.ac.ir No.2 and 3, Shabo Alley,Street No.18, Velenjak Avenue,Yemen Street, Shaheed Chamran,Tehran, 19857-43413
dc.relation.ispartofJournal of Reproduction and Infertility
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzScopus_20251023
dc.subjectHyaluronan Binding Assay
dc.subjectIntrauterine insemination
dc.subjectMild male factor infertility
dc.subjectPrediction
dc.subjectUnexplained infertility
dc.titleCan hyaluronan binding assay predict the outcome of intrauterine insemination in couples with unexplained or mild male factor infertility?
dc.typeArticle

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