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Öğe MPV, RDW, LAKTAT, NA ve Albumin Düzeyleriyle Yoğun Bakım Hasta Mortalitesi Arasındaki İlişki(Malatya Turgut Özal Üniversitesi, 2022) Aydın, Ahmet; Kaçmaz, Osman; Öterkuş, Mesut; Miniksar, Ökkeş HakanGiriş ve Amaç: Yoğun bakım hasta mortalitesine yaş, yatış süresi, mekanik ventilasyon ihtiyacı ve süresi, eşlik eden yandaş hastalıklar, enfeksiyon ve laboratuvar parametreleri gibi birçok parametrenin etkisi vardır. Çalışmamızda bu parametrelerden hangilerinin yoğun bakım hasta mortalitesi üzerine etkisi olduğunu araştırmayı amaçladık. Yöntemler: Retrospektif planlanan çalışmamıza hastanemiz yoğun bakım servisinde Ocak 2018-Aralık 2019 tarihleri arasında yatan 18 yaş üstü 295 hasta dahil edildi. Taburcu ve ex olan hastalar olarak iki gruba ayrıldı. Gruplar arasında, parametrelerin mortalite ile arasındaki ilişkisi karşılaştırıldı. Bulgular: %53,6’sı (n:158) erkek olan hastaları yaş ortalaması ise 76 yıl olarak bulundu. Nörolojik hastalıkların varlığı, ileri yaş ve yüksek Apache II skoru mortalite oranında anlamlı artışa sebep olmaktadır. Entübe olarak kabul edilen hastalarda mortlite daha yüksekti. Yüksek laktat , yüksek RDW seviyesi ve düşük albumin düzeyi, artmış mortalite ile ilişkili bulundu. Sodyum ve MPV değerinin ise mortalite ile anlamlı bir ilişkisinin olmadığı saptandı. 15 günden az yatışı olan hastalarda ise mortalite oranı daha düşük bulundu. Sonuç: RDW, Albumin ve laktat değerlerinin yoğun bakımda yatan hastaların prognozu etkilediği görüldü. Bu değerlerin takibinin; erken dönemde tedavinin başlanabilmesi açısından fayda sağlayacaktır.Öğe Different Plant Sporopollenin Exine Capsules and Their Multifunctional Usage(American Chemical Society, 2022) Atalay, Funda Ersoy; Culum, Ayşe Asiye; Kaya, Harun; Göktürk, Günay; Yiğit, Emelporopollenin exine capsules (SECs) are highly resistant to heat and various acids and bases. They are also cheap, highly porous, eco-friendly polymer biomaterials with stable microencapsulation capacity. Due to their strong and uniquely shaped exine layers, they can allow growth on metal oxide materials, as a biotemplate for use in different applications. In this study, first, a single SEC extraction method was applied to three different pollens from Pinus, Fraxinus excelsior, and Tilia. Scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) analysis, and thermogravimetric/differential thermal analysis (TGA/DTA) measurements both before and after the extraction process were performed to observe changes in surface area, morphology, porous structure, and degradation properties. The protein content and removal were analyzed by elemental and spectrophotometric analyses. Then, SECs were loaded by passive and centrifuge loading for drug delivery, and the loading capacities were analyzed by Fourier transform infrared spectroscopy and spectrophotometry. The method was successful in opening the pores and maintaining the structural integrity of SECs. It was determined that the morphology and porosity affected the encapsulation efficiency. According to the loading capacities, Tilia SECs were the most efficient SECs for both loading methods. In addition, three different SECs were hydrothermally coated with cobalt and then heat-treated to obtain a metal oxide structure. A CO3O4supercapacitor electrode constructed using CO3O4-F. excelsior SEC powder had the best surface area parameters. The electrode showed a maximum specific capacity of 473 F/g for over 3000 continuous cycles of galvanostatic charge-discharge (GCD). © 2022 American Chemical Society. All rights reserved.Öğe Cryoprotective Effect of Vitamin E Supplementation of Different Extenders on Quality and Fertilizing Ability of Frozen-Thawed Brown Trout Sperm(Mary Ann Liebert, Inc, 2021) Bozkurt, Yusuf; Yavaş, İlker; Bucak, Mustafa Numan; Kıran, Tuğba Raika; Gül, AzizVitamin E is one of the most powerful antioxidants for prevention of cell damage resulting from cryopreservation, but its efficacy for cryopreserving brown trout sperm is still unclear. In this work, the protective effect of vitamin E on quality, fertilizing capacity, and DNA damage of brown trout (Salmo trutta macrostigma) sperm after cryopreservation was evaluated. Sperm samples were diluted at the ratio of 1:10 with three different extenders (E): (E-I): 300?mM glucose, 10% egg yolk; (E-II): 33.3?mM glucose, 5.1?mM NaCl, 0.5?mM NaHCO3,, 15% DMA; and (E-III): 61.6?mM NaCl, 134.2?mM KCl, 1.9?mM CaCl2, 0.8?mM MgCl2, 2.3?mM NaHCO3 in distilled water. Each extender was supplemented with 10% DMSO and different concentrations of vitamin E at 0.1, 0.5, and 1.0?mM. Spermatozoa frozen without vitamin E (0?mM, control) and fresh sperm were also used. After dilution, the sperm was aspirated into 0.25?mL straws, frozen 3?cm above the liquid nitrogen (LN2) surface, and plunged into the LN2. Cell motility, viability, fertilization, and eyeing were determined in post-thawed samples. DNA damage was determined by the comet assay after cryopreservation. Supplementation of 1?mM vitamin E to all extenders exhibited the best cryoprotective effect in terms of sperm motility, duration of motility, viability, fertility, and DNA integrity against cryopreservation damage, compared with 0.1, 0.5, and control group (0?mM) (p?Öğe Anatomy of parotid gland and it's secretory ducts in sheep(Polish Anatomical Society, 2021) Uzun Bağcı, Gökçe; Kamaşak, Burcu; Ulcay, Tufan; Aycan, KenanBackground: The parotid gland in sheep ends freely in front of the masseter muscle, and paracondylary section of occipital bone and extends deep until pterygoid extends of sphenoid bone and hyoid bone. The structure of salivary glands in mammals has been thoroughly studied histological and sialografic method. In this study, it was aimed to reveal the detailed anatomic features and race specific differences of the canal system of the parotid glands in Akkaraman sheep by using the corrosion cast technique. Materials and methods: 13 sheep parotid glands from 7 Akkaraman sheep were used in this study. Parotid glands were removed from their places with ducts. Measurements were made with a caliper from back to front, top to bottom and inside to outside. After dissection of the parotid glands, their volumes were measured according to the 'Archimedes principle'. Also, 13 sheep parotid glands were examined using the polyester resin method. Results: In the present study, our average metric results were: length of parotid duct was 10.92±1.027 cm, length of parotid gland was 5.87±1.04 cm, volume of parotid gland was 12.50±2.48 cm³, thickness of parotid gland was 0.75±0.36 cm and width of parotid gland was 4.07±0.43 cm. The average weight of the parotid gland of Akkaraman sheep was identified as 25.3 g. Accesoria parotid gland was not encountered in the current study. Conclusions: It was observed that polyester entered into the parotid duct and filled up until the acinus and made both acinus and secretion ducts well-examined ın this study. It was also observed that the parotid gland consisted of lobes and lobules. The average number of lobes was 12. The number of lobules in a lobe varied between 3-16, each lobe consists of an average of 9 lobules. It was found that each lobe has its own lobar duct.
