DSpace Arşivi :: by Yazar "Turan, Fatime Filiz" değerine göre listeleniyor

Listeleniyor 1 - 1 / 1

Therapeutic potential of caffeic acid phenethyl ester and its anti-inflammatory and immunomodulatory effects
(Spandidos Publ Ltd, 2015) Armutcu, Ferah; Akyol, Sumeyya; Ustunsoy, Seyfettin; Turan, Fatime Filiz
Caffeic acid phenethyl ester (CAPE), a naturally occurring compound isolated from propolis extract, has been reported to have a number of biological and pharmacological properties, exerting antioxidant, anti-inflammatory, anticarcinogenic, antibacterial and immunomodulatory effects. Recent in vivo and in vitro study findings have provided novel insights into the molecular mechanisms involved in the anti-inflammatory and immunomodulatory activities of this natural compound. CAPE has been reported to have anti-inflammatory properties involving the inhibition of certain enzyme activities, such as xanthine oxidase, cyclooxygenase and nuclear factor-kappa B (NF-kappa B) activation. Since inflammation. and immune mechanisms play a crucial role in the onset of several inflammatory diseases, the inhibition of NF-kappa B represents a rationale for the development of novel and safe anti-inflammatory agents. The primary goal of the present review is to highlight the anti-inflammatory and immunomodulatory activities of CAPE, and critically evaluate its potential therapeutic effects.