Yazar "Kaygusuz, İkbal Cekmen" seçeneğine göre listele
Listeleniyor 1 - 7 / 7
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe A current method in gynecological cancer prediction: "Micronucleus": Review(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S. aysea@turkiyeklinikleri.com Turkocagi Caddesi No. 30 Balgat 06520, 2016) Eser, Ayla Açar; Gürbüz, Neslihan; Kaygusuz, İkbal Cekmen; Canbal, Metin; Koş???us, Aydin; Köşüş, NerminPrediction and early diagnosis of cancer are vital in gynecology. Studies have shown that both micronucleus (MN) and micronucleus tests (MNT)s can be used to predict cancers. Approximately 92% of all of the human malignancies occur in epithelial tissues. The MN assay in exfoliated cells is an innovative genotoxicity technique which holds promise for the study of epithelial carcinogens. Micronuclei are usually produced during the metaphase/anaphase transition of mitosis. If the process of cell division is disturbed, the sharing of the genetic material to the two daughter nuclei may be affected. The same situation will also occur if the chromosomes are broken or damaged by radiation, drugs and chemicals. Under these conditions, the genetic materials that are not included in the nuclei of the daughter cells will then form its own "micronucleus". A MNT is a special toxicological test that is usually employed in screening chemical compounds that are potentially genotoxic. The main objective of the test is to identify those genotoxic agents, which are capable of modifying the structure and segregation of chromosomes, in a specific way that enables the induction of micronuclei in interphase cells. MNT is used to determine carcinogenic agents that are capable of triggering off a specific type of cytogenetic damage, which lead to the formation of micronuclei containing lagging chromosome fragments or whole chromosomes. Recently MNT began to be used in gynecology and will be one of the most important parameter in prediction, prognoses and response to treatment of cancer in the near future. © 2018 Elsevier B.V., All rights reserved.Öğe Amylase in obstetrics and gynecology: Review(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S. aysea@turkiyeklinikleri.com Turkocagi Caddesi No. 30 Balgat 06520, 2016) Eser, Ayla Açar; Kaygusuz, İkbal Cekmen; Köşüş, Nermin; Koş???us, Aydin; İnegöl Gümüş, İlknurAmylase is one of the main enzymes of the digestive system. It is principally produced by the pancreas and the salivary glands. In the digestive system, its main function is digestion of carbohydrates to break down starch into maltose. Now, amylase has been widely recognized as a very important tool in the medical field. Too little or too much of amylase in the blood is an indication of a variety of problems, particularly with the pancreas. Now, salivary/serum/uterine amylase tests are being used extensively in the obstetrics and gynecology. These simple but wonderful tests have been found to be very effective and reliable, in the identification of certain gynecological diseases and disorders. For instance, the high level of amylase could be an early sign of ovarian cancer, ruptured ectopic pregnancy when the low levels of blood amylase can be a predictor of preeclampsia. Human uterine amylase may be related to infertility. The other related conditions may be hyperamylasemia in response to ritodrine or ephedrine and macroamylasemia in pregnant patients, etc. At the same time, amylase has now been identified as a stress marker and is consequently being used for identification of several stress-related complications that greatly affect women. Especially salivary amylase used to as a stress biomarker in pregnant patients. © 2018 Elsevier B.V., All rights reserved.Öğe Application of sentinel lymph node dissection in gynecologic cancers: Review(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2015) Balci, Hatice; Koş???us, Aydin; Kaygusuz, İkbal Cekmen; Köşüş, Nermin; Eser, Ayla Açar; Altindiş, AyşeSentinel lymph node (SLN), where the primary tumoral lymphatic flow firstly ends is the place with the highest possibility of tumoral involvement in case of metastasis from the primary tumor. Therefore; according to the lymphatic mapping hypothesis, if the sentinel node is negative in terms of metastasis, non-sentinel nodes are also expected to be negative. Several techniques have been reported to identify the sentinel nodes. These are blue dye labeling, radio labeling and combined labeling that comprise sequential application of blue dye and technetium (tc) labeling. Blue dye is the general procedure when injected into damaged tissue intraoperativly to distinguish the tumor tissue. SLN dissection application is used in vulva and cervix cancers more commonly in gynecologic cancers. For this purpose, in cases where tc-labeled nanocolloid is used, SLN detection rate has been found 100%. It has been reported that SLN detection rate was 80-86% in cervical cancer, 50-80% in endometrial cancer and a little lower than those in vulva cancer. The method of SLN is consolidating its role in the diagnosis of vulvar and cervical cancer day by day. However, the most frequently encountered problems in the application of the SLN are the cases which found negative for metastasis in histopathological examination but understood to have micro level metastases at ultra-staging. The main prognostic factors in vulvar cancer is the nodal metastasis that independent from the primary tumor size. The conformity of routine use of SLN dissection without complementary lymphadenectomy is still controversial because inguinal region metastases is fatal in patients with vulvar carcinoma. However, most modern and promising future method is considering to be SLN biopsy. More studies are required for vulvar melanoma, vaginal, ovarial and endometrial cancers. © 2021 Elsevier B.V., All rights reserved.Öğe Bakri balloon application in postpartum haemorrhage(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2015) Eser, Ayla Açar; Koş???us, Aydin; Aslaner, Sevgi Yildirim; İnegöl Gümüş, İlknur; Kaygusuz, İkbal Cekmen; Köşüş, Nermin; Hizli, DenizObjective: To evaluate effectiveness of Bakri Balloon in post-partum haemorrhage treatment. Post-partum haemorrhage is the most common cause of maternal death in the world. It is potentially fatal complication of both vaginal and caesarean deliveries. In situations where medical interventions are unsuccessful in achieving haemostasis in cases of post-partum haemorrhage, either conservative or invasive surgical therapies are needed. Ultimately hysterectomy may be required. Invasive surgical interventions are associated with co-morbidities and potential implications for future fertility. Among the more conservative interventions are intrauterine balloon tamponade such as the Bakri balloon. Material and Methods: In this retrospective, observational study, records of 25 patients who were treated for post-partum haemorrhage in the Obstetrics and Gynecology Clinic of Turgut Ozal University Hospital, between January 2009 and August 2014 were examined. Frequency and efficacy of interventions were investigated in terms of haemostasis achievement without recourse to hysterectomy. Results: In 12 women who underwent Bakri balloon placement, haemostasis was achieved in all patients without subsequent hysterectomy. By contrast, of 9 women who underwent arterial ligation, 77.8% required hysterectomy as opposed to 31.3% of the 16 women who did not undergo arterial ligation. Use of combinations of surgical techniques was also significantly associated with higher risk of hysterectomy when compared to single techniques. Conclusion: Use of Bakri balloon is a highly effective method in achieving haemostasis in post-partum haemorrhage without necessity of hysterectomy. © 2021 Elsevier B.V., All rights reserved.Öğe Sleep abnormalities in pregnancy: Review(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2015) Eser, Ayla Açar; Kaygusuz, İkbal Cekmen; İnegöl Gümüş, İlknur; Koş???us, Aydin; Köşüş, NerminPregnancy and sleep disorders are strongly correlated. Sleep disorders commonly experienced in pregnancy include insomnia, restless legs syndrome, excessive daytime sleepiness and sleep disordered breathing, for example sleep apnea. Causes can be physical discomfort, hormonal changes, alterations in respiratory physiology and psychological and emotional upheaval. Incidence of the different types of sleep disorders varies depending on pregnancy trimester. The first trimester is associated with excessive daytime sleepiness, although this can continue throughout pregnancy. Physical factors such as nausea and vomiting and hormonal changes are important causes. By the second trimester, hormonal changes are stabilising but women may still suffer sleep problems due to enlarged abdomen causing low back pain, abrupt fetal movements, heartburn and nocturia. In the third trimester, the majority of women suffer from sleep problems. Incidence of insomnia and restless legs syndrome reach their maximum. Sleep disordered breathing issues including sleep apnea, snoring and hypoventilation are also more common, influenced by rising progesterone levels, disordered and periodic breathing, excessive weight gain and altered neck circumference. Sleep disorders in pregnancy have been associated with adverse maternal and fetal outcomes. Treatment options include improving sleep hygiene, exercise, positional therapy, continuous positive airway pressure, behavioural therapies and, where the sleep disorders are refractory to these types of interventions, short-term pharmacological treatment with suitable hypnotics. Postpartum, many of the pregnancy-associated sleep disorders resolve, however many women continue to experience excessive daytime sleepiness and both pre-and post-partum sleep disorders have been linked to incidence of post-natal depression. © 2021 Elsevier B.V., All rights reserved.Öğe The association between serum follicle-stimulating hormone levels and the success of microdissection testicular sperm extraction in patients with azoospermia(Urology and Nephrology Research Centre info@unrc.ir, 2014) Yıldırım, Mehmet Erol; Koç, Akif; Kaygusuz, İkbal Cekmen; Badem, Hüseyin; Karataş, Ömer Faruk; Çimentepe, Ersin In; Ünal, DoğanPurpose: To evaluate the predictive power of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, testicular biopsy histology and male age were evaluated with respect to the success of sperm retrieval in a microdissection testicular sperm extraction (microTESE) procedure, pregnancy and live birth rates. Materials and Methods: We examined the data of 131 infertile men with non-obstructive azoospermia, who have undergone microTESE operation. The men were classified into two groups based on serum follicle-stimulating hormone (FSH) levels ? 15 mIU/mL (group 1) and > 15 mIU/mL (group 2). Results: Group 1 consisted of 59 patients (mean age 36.2 ± 6.2 years) and group 2 consisted of 72 (mean age 38.8 ± 7.4 years) patients. Sperm retrieval and pregnancy rates were 66.1% and 16.9% in normal FSH group, respectively. These parameters were higher than those of men with FSH > 15 (43% and 8.3%, respectively). Only 128 patients had histopathological diagnosis. Sperm was retrieved from 12/30 (40%) patients with maturation arrest, 9/29 (31.03%) patients with seminiferous tubules atrophy, 14/40 (35%) patients with sertoli cell only syndrome and 13/13 (100%) of patients with hypospermatogenesis. There was no statistically significant difference in pathological diagnosis between pregnancy and live birth rates. Conclusion: These results demonstrate that there is a significant difference with sperm retrieval, pregnancy rates and live birth rates comparing the FSH levels. Histopathological findings did not associate with successful microTESE, pregnancy rates and live birth rates. © 2015 Elsevier B.V., All rights reserved.Öğe Totally inverted cervix due to a huge prolapsed cervical myoma simulating chronic non-puerperal uterine inversion(Elsevier Ltd, 2014) Turhan, Nilgün Öztürk; Simavli, Serap Aynur; Kaygusuz, İkbal Cekmen; Kasap, BurcuINTRODUCTION Inversion of the uterus is an extremely rare complication of the non-puerperal period and is commonly caused by benign submucous, especially fundal, leiomyomas. A case of a totally inverted cervix due to a prolapsed huge cervical leiomyoma mimicking chronic non-puerperal uterine inversion in a perimenopausal woman is presented. PRESENTATION OF CASE A 52-year-old perimenopausal woman was admitted to our clinic with an ulcerated, necrotic, infected and swollen prolapsed mass. Gynecologic history revealed that she was advised myomectomy because of her cervical myoma 2 years ago but she refused to have an operation as she believed that her positive thoughts would shrink the myoma. Presumed diagnosis before surgery was chronic non-puerperal uterine inversion. An intraoperative diagnosis was totally inverted cervix due to a huge cervical leiomyoma. Vaginal hysterectomy without adnexectomy, was performed. CONCLUSION This is the first case in the literature which a totally inverted cervix due to a prolapsed huge cervical leiomyoma. Cervical fibroids can grow in perimenopausal period and in extremely rare cases can cause total cervical inversion. © 2014 The Authors. © 2014 Elsevier B.V., All rights reserved.
