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Öğe CRP, HbA1c, lipid, and biochemical parameters and their relation with maternal visceral adipose tissue and subcutaneous fat tissue thickness(Tubitak Scientific & Technological Research Council Turkey, 2016) Duran, Muzeyyen; Kosus, Aydin; Kosus, Nermin; Turhan, NilgunBackground/aim: The aim of this study was to find whether maternal visceral tissue (VAT) or subcutaneous fat tissue (SCFT) thicknesses are associated with CRP, HbA1c, lipid, and biochemical parameters in the first trimester of pregnancy. Materials and methods: Ninety pregnant women were enrolled. Body mass index (BMI), VAT, and SCFT were measured. The best cutoff points for grouping subjects were found to be 4 cm for VAT and 2 cm for SCFT. Venous blood samples were collected. Results: VAT was higher than 4 cm in all cases with high BMIs. High CRP and HbA1c were found in 45.5% and 18.2% of cases with VAT over 4 cm, respectively. Conclusion: Besides overall obesity, VAT thickness is the most important parameter. Decreasing obesity may prevent pathologies caused by inflammation during pregnancy as well as decrease the risk for future metabolic and cardiovascular disorders.Öğe Does vitamin E prevent tubal damage caused by smoking? A light microscopy and animal study(Elsevier Science Bv, 2014) Duran, Muzeyyen; Ustunyurt, Emin; Kosus, Aydin; Kosus, Nermin; Turhan, Nilgun; Hizli, Deniz; Sarac, Gulce NazObjective: To assess the histomorphological effects of smoking on the cilia of fallopian tubes in mice and the effect of vitamin E on the negative effects of smoke. Study design: Eighteen 12-14 week-old Swiss albino type female mice were randomly divided into three groups, each consisting of six mice: Group A: control group; Group B: mice exposed to cigarette smoke; Group C: mice exposed to cigarette smoke together with vitamin E. Groups B and C were exposed to cigarette smoke for 10 weeks. After 10 weeks, tubal excision was performed in all animals. Histopathologic examination of excised tubal tissue was conducted under light microscopy. Results: The number of cilia was significantly lower in Group B. Although not statistically significant, the median number of cilia in Group C was measured to be higher than in Group B but lower than in Group A. Conclusion: Based on the results, it can be concluded that smoking decreases tubal cilia numbers. Supplementation by vitamin E may treat or at least help to slow down the decrease in number of cilia caused by smoking; therefore it could be used therapeutically in the treatment of smoking-related tubal damage. Crown Copyright (C) 2014 Published by Elsevier Ireland Ltd. All rights reserved.Öğe Effect of Underlying Infertility Factors on Second Trimester Serum Screening Results(Sci Printers & Publ Inc, 2014) Kosus, Nermin; Kosus, Aydin; Duran, Muzeyyen; Turhan, Nilgun O.OBJECTIVE: To determine whether assisted reproductive technologies (ART) alone or an underlying cause of infertility has any effect on second trimester serum screening results. STUDY DESIGN: Second trimester serum screening results of ART pregnancies of women with polycystic ovary syndrome (IVF-P group) were compared with those of women who underwent ART dike to male factor infertility (IVF-M group) and of women who conceived spontaneously. RESULTS: Comparison of the groups for a-fetoprotein, beta-hCG, and beta-hCG multiples of the median (MoM) revealed a significant difference between the IVF-M and control groups. Comparison of groups for unconjugated estriol (uE(3)) and uE(3) MoM levels revealed a statistically significant difference between the IVF-P versus the control groups. CONCLUSION: It seems advisable to use a population of ART pregnancies, preferably divided by type of treatment and the etiology of the infertility, when establishing median curves for second trimester serum screening markers.Öğe Relation between serum PAPP-A level and umbilical cord thickness during first trimester of pregnancy(Taylor & Francis Ltd, 2014) Duran, Muzeyyen; Kosus, Aydin; Kosus, Nermin; Turhan, Nilgun O.Purpose: To evaluate the relation between umbilical cord diameter versus pregnancy associated plasma protein-A (PAPP-A) level in first trimester women. Method: Cord diameter were measured and patients were divided into two groups according to frequency distribution analysis as below or above 3.7 mm for free loop diameter (FCD) and below or above 3.4 mm for cord measurement at umbilicus (ACD). Groups were compared with each other. Results: Strong correlations were found between ACD versus PAPP-A. Conclusion: By using strong correlation between ACD versus PAPP-A, it may be possible to reduce unnecessary amniocentesis due to false positive screening results.Öğe Treatment of Ruptured Ovarian Endometrioma with Extremely High CA 125, Moderately High CA 19-9 and CA 15-3 Level(Derman Medical Publ, 2013) Duran, Muzeyyen; Kosus, Aydin; Kosus, Nermin; Duvam, Candan; Kafali, HasanIn this case report, a ruptured ovarian endometrioma with a very high CA-125 level, moderately elevated CA 19-9, and CA 15-3 levels is presented. A 20 years old patient, complaining from pelvic pain, 5 cm adnexial mass was detected on left side. Biochemical examination was revealed very high CA-125 value (2556IU/ml), moderately elevated CA 19-9 (134IU/ml), and CA 15-3 (65IU/ml) values. Laparoscopy was done and a ruptured ovarian endometrioma of 5 cm was seen during operation. After the total excision of the cyst, tumor markers fell rapidly. Very high CA-125 value, moderately elevated CA19-9, and CA 15-3 values can be seen in cases with ruptured endometrioma. In young patients, endometrioma must be considered firstly and laparoscopy should be applied instead of more invasive methods unless there was any finding or strong suspicion about malignancy.
