Malatya Turgut Özal Üniversitesi Kurumsal Akademik Arşivi
DSpace@Özal, Malatya Turgut Özal Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
The effects of lornoksikam and intravenous iboprofen in lower extremity ischemia reperfusion injury
(Wiley-Blackwell, 2016) Kucuk, A.; Aydin, M. E.; Koc, D. S.; Sivgin, V.; Arslan, M.; Comu, F. M.; Kosem, B.
[Abstract Not Available]
The impact of IL-33 in absence epilepsy
(Wiley-Blackwell, 2014) Akkilik, Z. Seckin; Gurol, G.; Sari, S.; Arabaci, S.; Yukselten, Y.; Guneri, D.; Ekici, F.
[Abstract Not Available]
Role of ADAMTS2 and ADAMTS5 Genes in Radioiodine Induced Damage to the Salivary Glands of Rats: Genetic, Immunohistochemical and Histopathological Evaluations
(Springer, 2016) Sadic, M.; Demirel, K.; Halacli, S. O.; Karakok, E.; Koca, G.; Ekinci, O.; Demircan, K.
[Abstract Not Available]
A disintegrin-like metalloproteinase with thrombospondin motif 8 expression analysis in OUMS-27 chondrosarcoma cells before and after insulin administration
(Natl Inst Science Communication-Niscair, 2016) Erden, Gonul; Akyol, Sumeyya; Comertoglu, Ismail; Altuntas, Aynur; Cakmak, Ozlem; Ugurcu, Veli; Yukselten, Yunus
A disintegrin-like and metalloproteinase with thrombospondin motif 8 (ADAMTS8) is a secreted protease with anti-angiogenic properties. It inhibits vascular endothelial growth factor (VEGF) induced angiogenesis and suppresses fibroblast growth factor 2 (FGF-2) induced vascularization. Angiogenesis and extracellular matrix degradation are the key events in tumor progression, and ADAMTS8 is also known to be a member of the aggrecanases family. In the present study, we investigated the expression levels of ADAMTS8 in chondrosarcoma cells to elucidate the effect of insulin on the tumor cells in terms of ADAMTS production. The OUMS-27 cells were cultured and separately exposed to 10 mu mol/mL insulin up to 11 days in Dulbecco's modified Eagle's medium. After specific time limits (days 1, 3, 7, and 11), the culture was terminated and RNA was isolated using TRIzol reagent and converted to cDNA. The expression levels of ADAMTS8 were evaluated by qRT-PCR. The ADAMTS8 expression in OUMS-27 cells exhibited about 4-fold decrease following insulin treatment on day 11. Statistically significant differences were noted between the control and day 1 (P = 0.008), day 7 (P = 0.047) and day 11 (P = 0.008) groups. The effect of insulin on chondrosarcoma cells in terms of ADAMTS8 expression has not been reported earlier. The decrease in ADAMTS8 expression could be considered as a novel finding that has the potential to explain some pathophysiological mechanisms of tumor cells. Furthermore, the finding could also shed some light on the relationships between matrix degradation and insulin treatment in vitro.
A Study on the Depiction of Disability in Illustrated Story Books
(Expert Projects Publishing, 2015) Gonen, Mubeccel; Dursun, Aylin; Bilir, Zeynep Topcu; Tarman, Ilknur; Nur, Imray
The aim of the present study is to examine illustrated storybooks depicting people with disabilities, in terms of their content and the type of disabilities they feature and to analyze the disabilities in the books that could be reached. The study was carried out in the survey design. Within the scope of the study, three largest bookstores in Ankara, Turkey and the websites offering online book shopping were surveyed and 234 illustrated story books were reviewed. Among these books, 30 illustrated storybooks, which depict people with disabilities, were included in the study. In order to examine the characters with illnesses and disabilities in the illustrated books, the study employed the Checklist to be used for Analysis of Children's Literature that includes People with Disabilities used in Inclusive Education, which was developed by Blaska. Although some examples found by the study results were rather negative, there are still some illustrated storybooks that depict disability correctly and help children respect people with disabilities by providing them with appropriate understanding of people with disabilities and disabilities themselves. However, despite the increase, it was seen that the number of books in this field is not sufficient.
