Rajabli, FaridInan, GulIlk, Ozlem2025-10-242025-10-2420131748-670X1748-6718https://doi.org/10.1155/2013/235825https://hdl.handle.net/20.500.12899/3644In family-based genetic association studies, it is possible to encounter missing genotype information for one of the parents. This leads to a study consisting of both case-parent trios and case-parent pairs. One of the approaches to this problem is permutation-based combined transmission disequilibrium test statistic. However, it is still unknown how powerful this test statistic is with small sample sizes. In this paper, a simulation study is carried out to estimate the power and false positive rate of this test across different sample sizes for a family-based genome-wide association study. It is observed that a statistical power of over 80% and a reasonable false positive rate estimate can be achieved even with a combination of 50 trios and 30 pairs when 2% of the SNPs are assumed to be associated. Moreover, even smaller samples provide high power when smaller percentages of SNPs are associated with the disease.eninfo:eu-repo/semantics/openAccessTransmission Disequilibrium Test; Gene; PermutationArticle10.1155/2013/2358252013237378582-s2.0-84877973271N/AWOS:000318936700001Q3