Erpolat, SevalCelik, Huseyin TugrulBozkurt, Bulent2025-10-242025-10-2420171642-395Xhttps://doi.org/10.5114/ada.2017.69315https://hdl.handle.net/20.500.12899/3955Introduction: Symptomatic dermographism (SD) is the most common form of physical urticaria. However, the role of neuroimmune mechanisms in SD is unclear. Aim: To investigate circulating levels of brain-derived neurotrophic factor (BDNF) in symptomatic dermographism. Material and methods: Thirty-two patients suffering from SD and 33 healthy subjects were included in the study. Serum BDNF levels were determined by a human enzyme-linked immunoassay (ELISA) kit. The serum C-reactive protein concentration and eosinophil counts in peripheral blood were evaluated. Results: The BDNF serum levels were detectable in both SD patients and healthy controls. The BDNF serum levels were significantly higher in patients with SD compared with healthy controls (p = 0.004). There was a positive but weak correlation between serum BDNF and CRP levels; it was not statistically significant (r = 0.211, p = 0.255). There was also a positive but weak correlation between serum BDNF and eosinophil counts; it was not statistically significant (r = 0.271, p = 0.141). Conclusions: The present study shows that BDNF is increased in the serum levels of patients with SD, suggesting a role for BDNF in the pathophysiology of this disorder.eninfo:eu-repo/semantics/openAccesssymptomatic dermographism; brain-derived neurotrophic factor; neurotrophinArticle10.5114/ada.2017.69315344346349289517102-s2.0-85026665048Q2WOS:000408254400010Q3