AYBEK, Sumeyya DenizATES, HACI OMERSONDAS, Saime SEZERGul, AliTAKCI, SAHINSEYYAH, BUKET ALTINTAS2025-10-242025-10-2420222602-30322602-3040https://doi.org/10.17826/cumj.1124468https://search.trdizin.gov.tr/tr/yayin/detay/1149661https://hdl.handle.net/20.500.12899/2279Purpose: The aim of this study was to investigate whether there is a relationship between surfactant protein B (SFTPB) C1580T polymorphism and acute bronchiolitis. Materials and Methods: The study analyzed the allele frequency and genotype distribution for the SFTPB C1580T polymorphism using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique in 103 acute bronchiolitis infants and 102 healthy infants. Results: The results showed no association between SFTPB C1580T polymorphism and clinical characteristics of acute bronchiolitis. The distribution of the CT genotype was higher in acute bronchiolitis infants (43%) than in healthy subjects (39%) and distribution of the TT genotype was found lower in acute bronchiolitis infants (38%) than in healthy subjects (41%). No significant differences in genotype distribution and allele frequency for the SFTPB C1580T polymorphism were found between case group and control group Conclusion: SFTPB C1580T gene polymorphism plays no important role in susceptibility to acute bronchiolitis. Further work on the relevance of SFTPB C1580T polymorphism in larger cohorts will require validating our results.eninfo:eu-repo/semantics/openAccessBiyolojiMikrobiyolojiKulakBurunBoğazPediatriGenetic polymorphismAcute bronchiolitisSFTPB genesurfactant proteinArticle10.17826/cumj.1124468474144014461149661