Aydin, DuyguYildirim, MehmetAyyildiz, MustafaAgar, Erdal2025-10-242025-10-2420131300-01441303-6165https://doi.org/10.3906/sag-1204-7https://search.trdizin.gov.tr/tr/yayin/detay/211642https://hdl.handle.net/20.500.12899/3849Aim: To evaluate the effects of coadministration of vitamins alpha-tocopherol, ascorbic acid, and pyridoxine with memantine on a penicillin-induced experimental epilepsy model in rats so as to clarify the eventual interaction between these vitamins and the N-methyl-D-aspartate (NMDA) system. Materials and methods: The epileptic focus was produced by intracortical penicillin G potassium injection. The effects of intraperitoneal injections of memantine, memantine + alpha-tocopherol, memantine + ascorbic acid, and memantine + pyridoxine combinations on epileptiform activity were evaluated in electrocorticogram recordings. Results: The antiepileptiform effects appeared earlier in all memantine and vitamin coadministrated groups compared to the memantine-alone group, but the difference between the groups was not statistically significant considering the frequency and amplitude of the epileptiform activity. Conclusion: Coadministration of vitamins does not enhance the antiepileptiform activity of memantine in penicillin-induced epilepsy in rats. However, this coadministration causes the earlier appearance of antiseizure effects. Since moderate doses of these vitamins have no side effects, it might be a good idea to use them with NMDA blockers to provide an earlier antiepileptic effect.eninfo:eu-repo/semantics/openAccessExperimental epilepsy; NMDA; memantine; ascorbic acid; pyridoxine; alpha-tocopherolArticle10.3906/sag-1204-74322452502-s2.0-84875065735Q1211642WOS:000321227500011Q3