Kosus, NerminKosus, AydinDuran, MuzeyyenTurhan, Nilgun O.2025-10-242025-10-2420140024-77581943-3565https://hdl.handle.net/20.500.12899/4074OBJECTIVE: To determine whether assisted reproductive technologies (ART) alone or an underlying cause of infertility has any effect on second trimester serum screening results. STUDY DESIGN: Second trimester serum screening results of ART pregnancies of women with polycystic ovary syndrome (IVF-P group) were compared with those of women who underwent ART dike to male factor infertility (IVF-M group) and of women who conceived spontaneously. RESULTS: Comparison of the groups for a-fetoprotein, beta-hCG, and beta-hCG multiples of the median (MoM) revealed a significant difference between the IVF-M and control groups. Comparison of groups for unconjugated estriol (uE(3)) and uE(3) MoM levels revealed a statistically significant difference between the IVF-P versus the control groups. CONCLUSION: It seems advisable to use a population of ART pregnancies, preferably divided by type of treatment and the etiology of the infertility, when establishing median curves for second trimester serum screening markers.eninfo:eu-repo/semantics/closedAccessalpha-fetoprotein; human; Down's syndrome; estriol; HCG-beta; infertility; polycystic ovary syndrome; reproductive technology; assisted; screening; second trimester screeningArticle591-2768024597291WOS:000330334800015Q4