Yildirim, Mehmet ErolBadem, HuseyinCakmak, MuzafferYilmaz, HakkiKosem, BahadirKaratas, Omer FarukBayrak, Reyhan2025-10-242025-10-2420162080-48062080-4873https://doi.org/10.5173/ceju.2016.770https://hdl.handle.net/20.500.12899/3994Introduction To investigate whether there was a protective effect of melatonin on apoptotic mechanisms after an acute unilateral obstruction of the kidney. Material and methods A total of 25 rats consisting of five groups were used in the study, designated as follows: Group 1: control, Group 2: sham, Group 3: unilateral ureteral obstruction treated with only saline, Group 4: unilateral ureteral obstruction treated with melatonin immediately, and Group 5: unilateral obstruction treated with melatonin one day after obstruction. Melatonin was administered as a 10 mg/kg dose intraperitoneally. The kidneys were evaluated according to the apoptotic index and Ki-67 scores. Results Comparison of all obstruction groups (Group 3, 4, and 5), revealed that the apoptotic index was significantly higher in Groups 1 and 2. Despite melatonin reduced apoptotic mechanisms in Groups 4 and 5, there was no significant difference between Groups 4 and 5 in terms of the reduction of apoptosis. However, the reduction of apoptosis in the melatonin treated group did not decrease to the level of Groups 1 and 2. Conclusions Despite melatonin administration, which significantly reduces the apoptotic index occurring after acute unilateral ureteral obstruction, the present study did not observe a return to normal renal histology in the obstruction groups.eninfo:eu-repo/semantics/closedAccessmelatonin; kidney; obstruction; apoptosis; hypoxia; antioxidantArticle10.5173/ceju.2016.770692225230275515632-s2.0-84975159422Q3WOS:000378596400017N/A