Erken, Haydar AliKoc, Emine RabiaErken, GultenGenc, OsmanCelik, Huseyin TugrulGokce, Emre CemalAyada, Ceylan2025-10-242025-10-2420151573-31491573-3904https://doi.org/10.1007/s10989-014-9428-6https://hdl.handle.net/20.500.12899/3334NUCB2/nesfatin-1 has been implicated in various physiological functions such as feeding, drinking and the sleep-wake cycle, but its effect on epileptic activity is not clear. The aim of this study was to investigate the effects of NUCB2/nesfatin-1 on penicillin-induced epileptic activity and to answer the question of whether only NUCB2/nesfatin-1 cause epileptic activity in rats. Thirty-five rats were randomly assigned to the following seven groups: control, saline, penicillin, two different doses of NUCB2/nesfatin-1 (100 and 300 pmol), penicillin and two different doses of NUCB2/nesfatin-1 (100 and 300 pmol). EEGs were recorded before the injections and during the following 120 min. The EEG and motor findings of epileptic seizures were observed in NUCB2/nesfatin-1-injected groups. NUCB2/nesfatin-1 significantly increased the EEG power spectrum, spike frequency and amplitude values in penicillin-induced epileptic rats. These findings indicate that NUCB2/nesfatin-1 both causes epileptic activity and increases penicillin-induced epileptic activity in rats.eninfo:eu-repo/semantics/closedAccessEEG; Epilepsy; Nesfatin-1; NUCB2; SeizureArticle10.1007/s10989-014-9428-621129382-s2.0-84933041744Q2WOS:000348448700005Q4