Gozdemir, MuhammetDemircioglu, Ruveyda IremKarabayirli, SafinazSert, HuseyinMuslu, BunyaminUsta, BurhanettinYazici, Ummugulsum2025-10-242025-10-2420161682-024Xhttps://doi.org/10.12669/pjms.323.9174https://hdl.handle.net/20.500.12899/3708Objectives: Local anesthetic infiltration is also a process of a painful process itself. INJEX (TM) technology, known as Needle-free drug delivery system, was designed for reducing the pain associated with cutaneous procedures. We conducted a prospective, randomized trial to evaluate the application of lidocaine with INJEX (TM) system and 27-gauge needle. Methods: A total of 60 consecutive patients were allocated to receive either INJEX group or 27-gauge needle group. Local anesthetic infiltration was applied two minutes before epidural needle insertion. Results: Mean VAS, at the time of local anesthetic injection was 0 for group I and 2 for group II. When the effect of epidural needle insertion was compared, the mean VAS score was one versus two for Group-I versus Group-II, respectively. Lidocaine applied with the INJEX (TM) system before epidural needle insertion significantly reduced the intensity of pain during that procedure and was least effective the lidocaine applied with the 27-gauge needle and patients felt less pain during at the time of local anesthetic injection in Group-I. Conclusion: Needle-free delivery of lidocaine is an effective, easy to-use and noninvasive method of providing local anesthesia for the epidural needle insertion.eninfo:eu-repo/semantics/openAccessNeedle Free; Injection; Local Anesthetic delivery; TechnologyArticle10.12669/pjms.323.917432375676127375728WOS:000377706400047Q3