Pehlivan, SultanGurses, Murat SerdarUral, Mustafa NumanAkyol, SumeyyaEren, FilizInanir, Nursel TurkmenGulec, Mehmet Akif2025-10-242025-10-2420160007-50271943-7730https://doi.org/10.1093/labmed/lmw022https://hdl.handle.net/20.500.12899/3561Objective: To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI. Methods: Thirty autopsied individuals were allocated into 2 groups, namely, a study group of individuals who died of myocardial infarction (n = 20), and a control group who died of trauma (n = 10). We performed standard immunohistochemical staining on myocardial tissue specimens, studying anti-ADAMTS1, anti-versican, and anti-versican C terminal peptide sequence (DPEAAE) fragments. Results: Strong, diffuse staining was observed throughout myocardial tissue for ADAMTS1 in the 2 groups. However, in the study group, we observed no expression for ADAMTS1 around fibrotic areas but detected slight staining in coagulative and necrotic zones. Conclusion: Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI.eninfo:eu-repo/semantics/openAccessADAMTS1; myocardial infarction; versican; fragmented versican; postmortem; diagnosisArticle10.1093/labmed/lmw022473205212273468682-s2.0-85014440250Q3WOS:000381879800007Q4