Aldemir, SecilAcar, MuradiyeOcak, ZeynepDalbudak, ErcanYigitoglu, Muhammet RamazanGunduz, Esra2025-10-242025-10-2420161017-7833https://doi.org/10.5455/bcp.20151003063454https://search.trdizin.gov.tr/tr/yayin/detay/201005https://hdl.handle.net/20.500.12899/4011Objective: Obsessive-compulsive disorder (OCD) is a frequent neuropsychiatric disorder, in which genetic factors play important causative roles. We investigated the roles of the (-1019 C/G) promoter region polymorphism of 5-HTR1A and the G861C coding region polymorphism of 5-HTR1B genes in susceptibility to OCD in a Turkish population. Methods: Two single nucleotide polymorphisms, 5-HTR1A (rs6296) and 5-HTR1B (rs6295) genes were genotyped in 76 OCD patients and 57 healthy controls that were unrelated, using PCR-RFLP method. Results: We did not observe any difference in the genotype distributions of rs6296 and rs6295 between the OCD patient and control groups. Conclusions: As far as we know, our study is the first to establish the association of genetic variants 5-HTR1A (rs6296) and 5-HTR1B (rs6295) with OCD in a Turkish population. Based on our results, the relationship between polymorphisms of 5-HTR1A (rs6296) and 5-HTR1B (rs6295) with OCD do not seem.eninfo:eu-repo/semantics/closedAccessgenetics; OCD; 5HTT geneArticle10.5455/bcp.201510030634542621341402-s2.0-84975486778N/A201005WOS:000383390400006Q4