Totan, YukselGuragac, Fatma B.Guler, Emre2025-10-242025-10-2420151057-08291536-481Xhttps://doi.org/10.1097/IJG.0000000000000168https://hdl.handle.net/20.500.12899/3569Purpose:To identify the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in healthy Turkish children measured by high-definition optical coherence tomography (HD-OCT).Patients and Methods:This institutional study involved 296 eyes from 296 healthy children aged between 3 and 17 years. Each child underwent a dilated eye examination, cycloplegic refraction, and axial length measurement using Nidek AL-Scan optical biometer. Macular scan was used to measure the GC-IPL thickness, and peripapillary retinal nerve fiber layer (RNFL) thickness was measured using the HD-OCT (Cirrus HD-OCT). Right eye of each subject was selected for analysis.Results:A total of 296 children (125 boys, 171 girls) were included in this study. The mean age of the children was 9.624.10 years (range, 3 to 17 y). The mean spherical equivalent was -0.09 +/- 1.49 D. The mean AL was 23.03 +/- 1.03 mm. The mean overall GC-IPL thickness was 83.44 +/- 5.52 m and RNFL thickness was 96.91 +/- 10.21 m. They were thicker than has been reported in adults. According to age-adjusted multiple regression analyses significant predictors of mean GC-IPL thickness were peripapillary RNFL thickness and AL (P<0.001).Conclusions:This study ensures a pediatric normative database of GC-IPL using spectral-domain OCT. This information may provide to diagnosis and monitoring of optic nerve diseases and glaucoma in children.eninfo:eu-repo/semantics/closedAccesschildren; ganglion cell layer thickness; retinal nerve fiber layer; high-definition optical coherence tomographyArticle10.1097/IJG.0000000000000168245e103e108253042802-s2.0-84931564824Q2WOS:000356375700013Q2