Yilmaz, HakkiGurel, Ozgul MalcokCelik, Huseyin TugrulSahiner, EnesYildirim, Mehmet ErolBilgic, Mukadder AyseBavbek, Nuket2025-10-242025-10-2420140886-022X1525-6049https://doi.org/10.3109/0886022X.2013.859528https://hdl.handle.net/20.500.12899/3785Purpose: The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD). Methods: CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls. Results: The mean CA 125 level in patients, 38.78 +/- 35.48 U/mL, was significantly higher than that found in healthy controls (9.20 +/- 4.55 U/mL; p = 0.003). Patients with elevated CA 125 levels (n = 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (r = 0.596, p<0.05) and C-reactive protein (CRP) levels (r = 0.439, p<0.05), as well as LVEDd (r = 0.599, p<0.001), LVESd (r = 0.750, p<0.001) and LV mass index (r = 0.378, p<0.05). In contrast, serum CA 125 levels were negatively correlated with albumin (r = -0.513, p<0.05) and hemoglobin (r = -0.475, p<0.05) as well as the EF (r = -0.878, p<0.0001). A depressed EF (beta = -1.121, p<0.0001) and increased CRP levels (beta = 0.247, p = 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model. Conclusions: Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction via inflammation in patients on maintenance HD.eninfo:eu-repo/semantics/openAccessCA 125; end-stage kidney failure; echocardiography; hemodialysis; inflammation; left ventricular systolic dysfunctionArticle10.3109/0886022X.2013.859528362210216242892622-s2.0-84896730439Q2WOS:000333168000010Q4