Yilmaz, H.Ucan, B.Sayki, M.Unsal, I.Sahin, M.Ozbek, M.Delibasi, T.2025-10-242025-10-2420151871-40211878-0334https://doi.org/10.1016/j.dsx.2014.04.009https://hdl.handle.net/20.500.12899/3414Background: There is growing consensus in the literature that inflammation plays a central role in the pathophysiology of obesity and type 2 diabetes mellitus (T2DM) and cardiovascular complications. Neutrophil-to-lymphocyte ratio (NLR) provides a simple method for assessment of inflammatory status and it is a new, inexpensive marker. The aim of the present study was to investigate the predictive value of preprocedural (before the OGTT) NLR on development of type 2 diabetes (T2DM) in morbid obesity patients (MOP). Methods: 306 MOP (body mass index >= 40 kg/m(2)) and 95 normal weight patients with normal OGTT [ fasting plasma glucose (FPG) < 100 mg/dL. Two-hour glucose during OGTT < 140 mg/dL] were evaluated in this study. Results: The mean +/- SD NLR of MOP was significantly higher than that of patients with normal weight healthy patients (3.67 +/- 0.95 vs. 1.82 +/- 1.02, P < 0.001, respectively). In receiver operating characteristics curve analysis, NLR > 3.12 had 79.2% sensitivity and 64.9% specificity in predicting T2DM. Logistic regression analysis showed that elevated NLR (OR: 2.577, 95% CI: 1.363-4.872, P = 0.004) was an independent variable for predicting T2DM in MOP. Conclusions: MOP have higher NLR than healthy controls. High NLR is a powerful and independent predictor of T2DM in MOP. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of T2DM with MOP. (C) 2014 Diabetes India. Published by Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessMorbid obesity; Neutrophil-to-lymphocyte ratio; Inflammation marker; Type 2 diabetes mellitusArticle10.1016/j.dsx.2014.04.00994299304254706462-s2.0-84988528110Q1WOS:000215401100019N/A