Armutcu, FerahAkyol, SumeyyaUstunsoy, SeyfettinTuran, Fatime Filiz2025-10-242025-10-2420151792-09811792-1015https://doi.org/10.3892/etm.2015.2346https://hdl.handle.net/20.500.12899/3829Caffeic acid phenethyl ester (CAPE), a naturally occurring compound isolated from propolis extract, has been reported to have a number of biological and pharmacological properties, exerting antioxidant, anti-inflammatory, anticarcinogenic, antibacterial and immunomodulatory effects. Recent in vivo and in vitro study findings have provided novel insights into the molecular mechanisms involved in the anti-inflammatory and immunomodulatory activities of this natural compound. CAPE has been reported to have anti-inflammatory properties involving the inhibition of certain enzyme activities, such as xanthine oxidase, cyclooxygenase and nuclear factor-kappa B (NF-kappa B) activation. Since inflammation. and immune mechanisms play a crucial role in the onset of several inflammatory diseases, the inhibition of NF-kappa B represents a rationale for the development of novel and safe anti-inflammatory agents. The primary goal of the present review is to highlight the anti-inflammatory and immunomodulatory activities of CAPE, and critically evaluate its potential therapeutic effects.eninfo:eu-repo/semantics/openAccesscaffeic acid phenethyl ester; anti-inflammatory activity; immunomodulatory effectReview Article10.3892/etm.2015.23469515821588261368622-s2.0-84925070736N/AWOS:000353849700005Q4