Köşüş, NerminKoşus, AydinDuran, MüzeyyenTurhan, Nilgün Öztürk2025-10-242025-10-2420140024-7758https://hdl.handle.net/20.500.12899/3234Objective:To determine whether assisted reproductive technologies (ART) alone or an underlying cause of infertility has any effect on second trimester serum screening results. Study Design: Second trimester serum screening results of ART pregnancies of women with polycystic ovary syndrome (IVF-P group) were compared with those of women who underwent ART due to male factor infertility (IVF-M group) and of women who conceived spontaneously. Results: Comparison of the groups for ?-fetoprotein, ?-hCG, and ?-hCG multiples of the median (MoM) revealed a significant difference between the IVF-M and control groups. Comparison of groups for unconjugated estriol (uE<inf>3</inf>) and uE<inf>3</inf> MoM levels revealed a statistically significant difference between the IVF-P versus the control groups. Conclusion: It seems advisable to use a population of ART pregnancies, preferably divided by type of treatment and the etiology of the infertility, when establishing median curves for second trimester serum screening markers. © Journal of Reproductive Medicine®, Inc. © 2014 Elsevier B.V., All rights reserved.eninfo:eu-repo/semantics/closedAccessAlpha-fetoproteinAssistedDown's syndromeEstriolHCG-betaHumanInfertilityPolycystic ovary syndromeReproductive technologyScreeningSecond trimester screeningArticle591-27680245972912-s2.0-84892881639N/A