Buğday, Muhammet SerdarÖksüz, Ersoy2021-05-182021-05-182021Buğday, Muhammet Serdar & Öksüz, Ersoy. (January 01, 2021). Drug-drug interactions in the risky population: elderly, urological patients admitted to the intensive care unit. Eastern Journal of Medicine, 26, 2, 236-241.1301-08831339-3886https://doi.org/10.5505/ejm.2021.04864https://hdl.handle.net/20.500.12899/134Drug-drug interactions are a common health problem. They cause more serious side effects and are more common in patients with multiple diseases, especially in the elderly. It was aimed herein to examine the frequency of drug -drug interactions in elderly patients treated in the intensive care unit due to urological diseases. This retrospective study was performed on hospital ized patients over the age of 85 years who had urologic diseases and were treated in the intensive care unit. Drug-drug interactions were evaluated using the Rx mediapharma and Lexi interact programs. A total of 91 different medications were administered to 100 patients. Of the patients, 87 had drug-drug interactions and the total number of drug-drug interactions was 550. When all of the interactions were examined, it was observed that drug - drug interactions were most often to cause side effects on the cardiovascular system, such as arrhythmia, hypotension, or hypertension (40%). The drugs that were most involved in drug-drug interactions were furosemide (n: 87), enoxaparin sodium (n: 74), and acetyl salicylic acid (n: 45). The results of the study showed that drug-drug interactions were seen quite frequently in elderly patients hospitalized due to primary urological diseases in the intensive care unit. The most common adverse drug reactions in these patients were bleeding, changes in the therapeutic levels of drugs, and hyperkalemia.eninfo:eu-repo/semantics/openAccessDrug-drug İnteractionsUrologyElderlyIntensive Care UnitsArticle10.5505/ejm.2021.048642622362412-s2.0-85104181025Q4