Karahan, Doğudal, şirvan elmasYılmaz, Nazlı Gül, Haci mehmet2025-10-242025-10-2420241300-932Xhttps://doi.org/10.5578/flora.2024031074https://search.trdizin.gov.tr/tr/yayin/detay/1262975https://hdl.handle.net/20.500.12899/2783Introduction: Sandfly fever virus, a member of the Phlebovirus (Bunyaviridae family), can cause sandfly fever, also known as “Pappataci fever”. This vector-related disease occurs primarily in endemic regions during the summer months. Epidemics may develop in different regions if favorable environmental conditions and vector transport are present. Laboratory changes, such as elevated transaminases and creatine kinase levels, leukopenia, and thrombocytopenia, may be observed in sandfly fever. In this study, we aimed to evaluate the laboratory results and progression of sandfly fever cases, which were concentrated in the conditions developing in the earthquakeaffected region. Materials and Methods: Seventeen sandfly fever cases who were followed up in our clinic between August and October 2023 were included in the study. These cases were patients who presented with non-specific complaints related to infection in the earthquakeaffected area after the February 6 Kahramanmaraş earthquake and had acute hepatitis with elevated transaminases, creatine kinase, and C-reactive protein (CRP). The study retrospectively evaluated the laboratory results and findings of cases positive for the sandfly fever virus. Results: Of the cases, 58.8% were male (n= 10), 41.2% were female (n= 7), with a mean age of 40.88 ± 19.59. The mean aspartate aminotransferase (AST) was calculated as 325.53 U/L, alanine aminotransferase (ALT) as 311.88 ± 282.36 U/L, alkaline phosphatase (ALP) as 109.64 ± 49.59 U/L, gamma-glutamyl transferase (GGT) as 80.82 ± 71.05 U/L, lactate dehydrogenase (LDH) as 564.47 ± 404.57 IU/L and creatine kinase (CK) as 872.38 U/L. Of the 17 cases, nine had leukopenia (53%), nine had neutropenia (53%), and five had lymphopenia (29.4%). Thrombocytopenia was observed in seven cases (41.1%). The mean CRP level was high at 3.78 mg/dL. Acute renal failure was also present in three cases. The cases were discharged after supportive treatment and observation, with improvements in both clinical and laboratory findings. Conclusion: Our study showed that sandfly virus-related epidemics may occur, particularly during warm months, when suitable conditions develop, such as after an earthquake. Additionally, it was determined that an acute hepatitis presentation, characterized by a significant increase in transaminases and creatine kinase, can be observed in sandfly virus infection. Our study also indicates that caution should be exercised regarding the potential for larger and more serious epidemics that may affect the region, especially during the summer months, if current conditions persist.eninfo:eu-repo/semantics/openAccessTıbbi Araştırmalar DeneyselGenel ve Dahili TıpPatolojiKulakBurunBoğazTıbbi Laboratuar TeknolojisiThrombocytopeniaLeukopeniaCreatine kinaseAcute hepatitisSandfly feverArticle10.5578/flora.20240310742933503561262975