Kayaoglu, KubraOzer, Duygu2026-06-192026-06-1920240279-36951938-2413https://doi.org/10.3928/02793695-20240322-02https://hdl.handle.net/20.500.12899/5132PURPOSE: To analyze the relationship between self -efficacy in protecting against substance use and loneliness in adolescents. METHOD: This descriptive, cross-sectional study comprised 400 adolescents. A Sociodemographic Data Form, Self -Efficacy for Adolescents Protecting Against Substance Abuse Scale (SEAPSAS), and Short -Form UCLA Loneliness Scale (ULS-8) were used for data collection. Regression analysis and Pearson correlation analysis, as well as descriptive statistics, were used in data analysis. RESULTS: Mean ULS-8 total score was 17.94 (SD = 5.07) and mean SEAPSAS total score was 68.78 (SD = 17.59). A weak significant negative relationship was found between mean ULS-8 total score and mean SEAPSAS subdimensions and total score. As a result of regression analysis, it was determined that ULS-8 total score negatively affected mean SEAPSAS total score by 24.9% (R-2 = 0.249; B = -1.713; p < 0.001). CONCLUSION: Loneliness in adolescents, which was observed to negatively impact self -efficacy in protecting against substance use, should be addressed by psychiatric nurses through prevention activities and support programs and services, such as early detection and intervention.eninfo:eu-repo/semantics/closedAccess[Keyword Not Available]Article10.3928/02793695-20240322-026292936385371062-s2.0-85203205748Q2WOS:001195969300001Q30000-0001-5800-5099