Ademoglu, Esra NurGorar, SuheylaKeskin, MugeCarlioglu, AyseUcler, RifkiErdamar, HusamettinCulha, Cavit2025-10-242025-10-2420172359-39972359-4292https://doi.org/10.1590/2359-3997000000288https://hdl.handle.net/20.500.12899/3741Objective: To investigate serum nesfatin-1 levels at 24-28 weeks of pregnancy in women newly diagnosed with gestational diabetes and determine the association of nesfatin-1 with several metabolic parameters. Subjects and methods: Forty women newly diagnosed with gestational diabetes at 24-28 weeks of pregnancy and 30 healthy pregnant women matched in age and gestational week were included in this cross-sectional study. Serum nesfatin-1 levels were analyzed using ELISA, and the relationship between nesfatin-1 and several metabolic parameters were assessed. Results: Serum nesfatin-1 levels were found to be lower in women with gestational diabetes compared to the pregnant women in the control sample (p = 0.020). Multiple linear regression analysis revealed that nesfatin-1 was lower in participants with gestational diabetes independently from gestational age, BMI, HOMA-IR, fasting plasma glucose, and age. In correlation analysis, the only variable that was found to have a statistically significant correlation with nesfatin-1 was gestational age (p = 0.015, r = 0.30). Conclusion: Lower nesfatin-1 levels in women with gestational diabetes compared to the control group at 24-28 weeks of gestation draws attention to nesfatin-1 levels in gestational diabetes and motivates further research in this area.eninfo:eu-repo/semantics/openAccessGestational diabetes; nesfatin-1; insulin resistanceArticle10.1590/2359-3997000000288615455459289771602-s2.0-85042000062Q3WOS:000416002900008Q3