Kaygusuz, IkbalSimavli, Serap AynurEser, AylaInegol Gumus, IlknurYuksel, SelcenIltemir Duvan, Zehra CandanKafali, Hasan2025-10-242025-10-2420141300-01441303-6165https://doi.org/10.3906/sag-1311-88https://search.trdizin.gov.tr/tr/yayin/detay/213209https://hdl.handle.net/20.500.12899/3871Background/aim: To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.eninfo:eu-repo/semantics/openAccessMean platelet volume; menopause; cardiovascular risk; hormone replacement therapy; lipid profileArticle10.3906/sag-1311-88446980984255521502-s2.0-84908059063Q1213209WOS:000344155900011Q4