Pala, MukaddesAltan, MehmetHanikoglu, Ferhatneselioglu, salimEREL, OzcanMetin, Gökhan2025-10-242025-10-2420222587-0319https://doi.org/10.30565/medalanya.1055424https://search.trdizin.gov.tr/tr/yayin/detay/1216485https://hdl.handle.net/20.500.12899/2435Aim: Thiol/disulfide homeostasis is an indicator of oxidative stress and antioxidant capacity. Ischemia-modified albumin (IMA) is an important marker for both oxidative stress and ischemia. We aimed to evaluate the possible effects of regularly performed moderate-intensity exercise on thiol/disulfide homeostasis, and IMA levels.Methods: Sprague Dawley rats were used. The study was composed of an Exercise group (EG, n=9) and Control group (CG, n=6). A 10-weeks swimming exercise was performed. Thiol/disulfide homeostasis measurement method was used in this study. IMA levels were measured by a cobalt-albumin binding method.Results: In the EG, total thiol levels were significantly higher compared to the CG (p<0.01). The disulfide/total thiol ratio was lower in the EG compared to the CG (p<0.01). We observed that there was a slight increase in IMA levels in EG (p=0.18). This increase was not statistically significant.Conclusion: Regularly performed moderate-intensity exercise has increased native and total thiol levels. Increase of thiol levels can prevent oxidative stress. Regularly performed moderate-intensity exercise programs appear to provide favourable effects on oxidative stress. eninfo:eu-repo/semantics/openAccessBiyolojiTıbbi Araştırmalar DeneyselHalk ve Çevre SağlığıOxidative stressSwimmingischemia-modified albuminthiol/disulfide homeostasisArticle10.30565/medalanya.1055424621201251216485