AKTAR, BEDRİYE SEDA KURSUN2025-10-242025-10-2420242602-277Xhttps://doi.org/10.32571/ijct.1389889https://search.trdizin.gov.tr/tr/yayin/detay/1243783https://hdl.handle.net/20.500.12899/2474A series of new chalcone derivatives (1-5) were synthesized as a result of the Claisen-Schmidt condensation of different substituted methyl aldehydes of 4?-Piperazinoacetophenone. Anticholinesterase (AChE and BChE) inhibitory activity and antidiabetic (?-glucosidase and ?-amylase inhibitory) activities of the synthesized compounds were examined. While compound 1 is the most active molecule in AChE (IC50= 16.29±0.44 ?M), BChE (IC50 = 10.19±0.04 ?M) and ?-amylase (IC50= 105.51±0.24 ?M) inhibitor activities; Compound 5 was found to be the most active molecule in ?-glucosidase inhibitor activity. In silico and molecular docking studies of compounds 1-5 were performed. According to molecular docking results, all molecules were found to be more active than the reference compounds.eninfo:eu-repo/semantics/openAccessMikroskopiSpektroskopiKimyaUygulamalıKimyaTıbbiToksikolojiBiyokimya ve Moleküler BiyolojiFarmakoloji ve EczacılıkMolecular dockingChalconeanticholinesterase inhibitory?-amylase inhibitory?-glycosidase inhibitoryArticle10.32571/ijct.13898898119261243783