Ergil, JulideKavak Akelma, FatmaOzkan, DeryaBumin Aydin, GozdeGurel, AyseAkinci, Melih2025-10-242025-10-2420151300-01441303-6165https://doi.org/10.3906/sag-1311-79https://search.trdizin.gov.tr/tr/yayin/detay/180840https://hdl.handle.net/20.500.12899/3870Background/aim: We aimed to compare the effectiveness of esmolol 1 mg/kg and lidocaine 1 mg/kg for injection pain and for the prevention of rocuronium-induced withdrawal response. Materials and methods: We enrolled a total of 81 patients in the study. Patients were randomly assigned to receive either 10 mL of 0.9% NaCl (Group P), esmolol 1 mg/kg (Group E), or lidocaine 1.0 mg/kg (Group L). A subparalyzing dose of rocuronium 0.05 mg/kg was administered to all patients and its effects were recorded. Anesthesia was induced with intravenous propofol and intravenous rocuronium 0.5 mg/kg in all groups. The withdrawal movements of the patient groups were subsequently graded. Results: There was a statistically significant difference in overall incidence of pain in group E and L compared to the placebo group after administrating the subparalyzed dose (no pain response: Group E = 81.5%, Group L = 77.8%, Group P = 14.8%) (P < 0.001). After intravenous administration of an intubating dose of rocuronium, the esmolol group had a significantly lower incidence of withdrawal movement than the other groups (no response: Group E = 81.5%, Group L = 63%, Group P = 22.2%) (P < 0.001). Conclusion: We found that esmolol significantly attenuates rocuronium-induced withdrawal movement and also reduces pain when used at subparalyzing doses.eninfo:eu-repo/semantics/openAccessEsmolol; rocuronium; lidocaine; withdrawal movement; injection painArticle10.3906/sag-1311-79454959963264228742-s2.0-84933048337Q1180840WOS:000359064200035Q4