The circulating alarin level was elevated in infertile women with poor ovarian reserve

Yıldırım, HakanGörkem, Ümit2021-07-132021-07-132021Yildirim, E., & Gorkem, U. (2021). The circulating alarin level was elevated in infertile women with poor ovarian reserve. Gynecological Endocrinology, 1-4.0951-35901473-0766https://doi.org/10.1080/09513590.2021.1950683https://hdl.handle.net/20.500.12899/279Objective: We aimed to reveal the association of serum alarin level with POR status of the infertile women in the present study. Methods: The eligibility criteria for this prospective cross-sectional study included a total of 92 infertile women attending the Hitit University Hospital, and all participant women were categorized into two main groups of ovarian reserve: (i) Poor ovarian reserve (POR) group (n = 40) based on ESHRE consensus and (ii) Control group (NOR) (n = 52). Results: The mean adjusted-ages and BMI values of the NOR and POR groups were statistically comparable (p = .057 and p = .600, respectively). The mean E2, FSH, and LH levels were elevated in the POR group (p < .001, for all). The mean AFC and AMH concentration were significantly reduced in the POR group (p < .001, for both). In addition, there was a significant increase in the serum alarin level in the POR group (p < .001). Pearson's analysis revealed that the mean BMI value of the POR group had a weak and negative correlation (r = 0.318, p = .046). Also, there was no correlation between serum alarin with E2 and FSH levels in both study groups. A weak and positive correlation was found between serum alarin and LH concentration only in the POR group (r = 0.318, p = .045). The mean AMH and AFC values were not significantly correlated with serum alarin levels. Conclusion: The circulating alarin level was significantly elevated in infertile women with POR patterns. In addition, the alarin level was significantly correlated with the serum LH concentration in the POR pattern.eninfo:eu-repo/semantics/closedAccessAlarinLuteinizing hormoneNormal ovarian reservePoor ovarian reserveThe circulating alarin level was elevated in infertile women with poor ovarian reserveArticle10.1080/09513590.2021.195068314342415542-s2.0-85110319351Q2WOS:000671486700001Q3