The effects of sponges soaked with chlorhexidine gluconate and metronidazole on safety of colonic anastomosis in an experimental model of peritonitis

dc.contributor.authorKanat, Burhan Hakan
dc.date.accessioned2022-05-05T09:31:59Z
dc.date.available2022-05-05T09:31:59Z
dc.date.issued2021en_US
dc.departmentMTÖ Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBACKGROUND: The present study aims to evaluate the use of the chlorhexidine gluconate and metronidazole impregnated compresses concerning anastomosis safety in the left colonic anastomosis in the presence of peritonitis. METHODS: This study was conducted on 21 Wistar-Albino-rats divided into three equal groups. After median laparotomy, the whole layer of the left colon was cut 2 cm over the pelvic peritoneum. The faeces were spread around the injury for fecal contamination. Then, fasia and skin were closed with 3/0 silk. After one day period, relaparatomy was performed. The abdomen was cleared isotonic sodium chloride with impregnated material before starting colonic anastomosis in the first group and then double layer colonic anastomosis was performed. In the second Group-II, abdomen was cleared with the metronidazole impregnated compresses then double layer colonic anastomosis was performed. In the group-III, abdomen was cleared with the chlorhexidine gluconate impregnated compresses then double layer colonic anastomosis was performed. Tissue hydroksiproline levels and anastomosis bursting pressures were measured and histopathologic findings on the anastomosis line were evaluated on the postoperative tenth day by performing relaparatomy. RESULTS: The highest anastomosis bursting pressure was found in Group-III (p<0.05). The highest tissue hydroksiproline level was found in Group-III (p<0.005 Group I-III, Group II-III). When histopathologic findings were evaluated by comparing the three groups in this study, the healing of the intestine tissue score was statistically insignificant between group-II and III, for both group-II and III, healing score was statistically significant higher than Group-I (p<0.05 Group I–III and Group I-II). CONCLUSION: Cleaning the abdomen before the anastomosis using antibacterial soaked material increased resection safety in the presence of peritonitis and anastomosis safety in primary anastomosis.en_US
dc.identifier.citationAksu, A., Bozan, M. B., Kutluer, N., Kanat, B. H., İlhan, Y. S., Türkoğlu, A., ... & Aksoy, N. (2021). The effects of sponges soaked with chlorhexidine gluconate and metronidazole on safety of colonic anastomosis in an experimental model of peritonitis. Turkish Journal of Trauma and Emergency Surgery, 27(2), 167-173.en_US
dc.identifier.doi10.14744/tjtes.2020.46682
dc.identifier.endpage173en_US
dc.identifier.issue2en_US
dc.identifier.startpage167en_US
dc.identifier.uri10.14744/tjtes.2020.46682
dc.identifier.urihttps://hdl.handle.net/20.500.12899/1047
dc.identifier.volume27en_US
dc.institutionauthorKanat, Burhan Hakan
dc.language.isoenen_US
dc.relation.ispartofUlus Travma Acil Cerrahi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnastomosis leakageen_US
dc.subjectchlorehexidin gluconateen_US
dc.subjectcolon anastomosisen_US
dc.subjectperitonitisen_US
dc.titleThe effects of sponges soaked with chlorhexidine gluconate and metronidazole on safety of colonic anastomosis in an experimental model of peritonitisen_US
dc.typeArticleen_US

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